6-Methoxybenzothiazole Synthesis Lab Report

2-iodo-6-methoxybenzothiazole synthesized from 2-amino-6-methoxybenzothiazole via a simple and convenient one-pot sequential diazotization–iodination procedure. A quantity of 1.814 g (0.01 mol) of 2-amino-6-methoxybenzothiazole dissolved in 3 ml of water under stirring at 0 °C. To this solution, 3 ml acetic acid and 4.5 ml of the 6 molar sulfuric acid added. Afterward, the reaction mixture stirred for 1 h to obtain a clear solution. Then, a solution of H_2 O (3 ml) containing 0.7g "NaN" O_2 (0.01 mol) added dropwise over 15 min at 0 °C. After stirring for 1 h, a solution of H_2 O (3 ml) containing 1.65 g of KI (0.01 mol) added slowly, till the evolution of nitrogen gas ceased. It took approximately 30 min to complete the iodination process.
Finally, the product extracted with EtOAc (3 × 12 m) and the combined organic layers washed with a 10% aqueous solution of 〖"Na" 〗_"2" "S" "O" _"4" , dried and re-crystallization in ethanol to obtain 2-iodo-6-methoxybenzothiazole as desired product.