Acute Wound Healing Case Study
1. Hemostasis
Hemostasis is the first stage of acute wound healing. It is characterized by the formation of a primary plug to prevent any further blood loss and exposure to environmental pathogens.
Once the tissue has been injured, the vascular and lymphatic vessels that are disrupted become constricted. The reparative coagulum is initiated as platelets adhere to the interior surfaces of the vessels as well as to a newly forming matrix of fibrin that together become the cruor of the thrombus, thus forming a provisional wound matrix. Together with the dehydration of surface bodily fluids, the thrombus and the scab decrease microvascular permeability.
2. Inflammation Once the outflow of blood has been controlled, the vessels dilate to allow an influx of migrating cells. This increase in cell number results in tissue edema, which is the physical characteristic of the inflammatory phase. There are two main components within this phase: tissue debridement (being the removal of dead or damaged tissue), and the immune response which …show more content…
These white blood cells are the first defence against infections, and will be depleted within two or three days after injury. They phagotcytose bacteria, and begin breaking down cellular debris and foreign materials. They do this by producing destructive proteases and oxygen free radicals, and by secreting antimicrobial cytotoxins.
The late inflammatory phase is characterized by circulating monocytes that undergo a phenotypic transition, during which they differentiate into tissue macrophages. Macrofages are essential to the wound healing process. These phagocytes ingest bacteria and apoptotic cells, such as depleted neutrophils. They are also responsible for tissue debridement by producing collagenases and elastases that break down devitalised
Hemostasis is the first stage of acute wound healing. It is characterized by the formation of a primary plug to prevent any further blood loss and exposure to environmental pathogens.
Once the tissue has been injured, the vascular and lymphatic vessels that are disrupted become constricted. The reparative coagulum is initiated as platelets adhere to the interior surfaces of the vessels as well as to a newly forming matrix of fibrin that together become the cruor of the thrombus, thus forming a provisional wound matrix. Together with the dehydration of surface bodily fluids, the thrombus and the scab decrease microvascular permeability.
2. Inflammation Once the outflow of blood has been controlled, the vessels dilate to allow an influx of migrating cells. This increase in cell number results in tissue edema, which is the physical characteristic of the inflammatory phase. There are two main components within this phase: tissue debridement (being the removal of dead or damaged tissue), and the immune response which …show more content…
These white blood cells are the first defence against infections, and will be depleted within two or three days after injury. They phagotcytose bacteria, and begin breaking down cellular debris and foreign materials. They do this by producing destructive proteases and oxygen free radicals, and by secreting antimicrobial cytotoxins.
The late inflammatory phase is characterized by circulating monocytes that undergo a phenotypic transition, during which they differentiate into tissue macrophages. Macrofages are essential to the wound healing process. These phagocytes ingest bacteria and apoptotic cells, such as depleted neutrophils. They are also responsible for tissue debridement by producing collagenases and elastases that break down devitalised