Altered Interictal Confusion
Areas with altered interictal perfusion may reflect local interictal differences in neuronal metabolic activity or density. This could reflect a preexisting difference in local brain structure and/or function or be the consequence of repetitive migraine attacks or chronic adaptive mechanisms, leading to neuroplastic changes in cortical and subcortical structures. Shorter-term explanations include changes related to, for instance, the migraine cycle, the presence of some degree of interictal cerebrovascular dysregulation in migraineurs, or a (migraine disease-related) systemic condition altering vessel wall characteristics that influence regional blood flow. Most if not all currently identified areas of altered perfusion have earlier been reported