Alzheimer's Disease And Dementia

The diseases that are characterized by an abnormal accumulation of α-synuclein (-Syn) aggregates within neurons, nerve fibers, or glial cells are collectively referred to as α-synucleinopathies [1]. The three main types of α-synucleinopathies are Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy. These disorders impact mainly the elderly population, therefore causing serious personal and economic burden in our aging societies. Among them the most common disease is PD, which displays both sporadic and familial forms. PD is the second most prevalent neurodegenerative disorder after Alzheimer’s disease, affecting up to 5% of people 65 years or older [2]. It is characterised by the development of motor difficulties