Alzheimer's Disease Hypothesis
Compare the effectiveness of neuroimaging approaches to predict the future onset, and to differentiate between the different clinical stages, of Alzheimer’s disease
Alzheimer’s disease is characterised as a dementia with the presence of amyloid plaques and neurofibrillary tangles which leads to neuronal cell death (Hardy & Higgins, 1992). The most major symptom shown in Alzheimer’s disease is the degeneration of cognitive function (memory, reasoning, attention, language etc.) and it is crucial to diagnose Alzheimer’s disease in the early clinical stages where the pathological damage isn’t too serious so to prevent further damage occurring at a rapid rate (Amieva, et al., 2008). Clinical diagnosis and research of Alzheimer’s disease use Braak staging to classify …show more content…
B. et al., 2010. The clinical use of structural MRI in Alzheimer disease. Nature Reviews Neurology, 6(2), pp. 67-77.
Hardy, J. A. & Higgins, G. A., 1992. Alzheimer's disease: the amyloid cascade hypothesis. Science, 256(5054), p. 184.
Johnson, K. A., Fox, N. C., Sperling, R. A. & Klunk, W. E., 2012. Brain Imaging in Alzheimer Disease. Cold Spring Harbor Perspectives in Medicine, 2(4).
Lee, B. C. P., Mintun, M., Buckner, R. L. & Morris, J. C., 2003. Imaging of Alzheimer's Disease. Journal of Neuroimaging, 13(3), pp. 199-214.
McGeer, P. L. et al., 1986. Comparison of PET, MRI and CT with pathology in a proven case of Alzheimer's disease. Neurology, Volume 36, pp. 1569-1574.
Mosconi, L. et al., 2008. Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias. Journal of Nuclear Medicine, 49(3), pp. 390-398.
Mueller, S. G. et al., 2005. Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimer's & Dementia, 1(1), pp. 55-66.
Smith, A. D. & Jobst, K. A., 1996. Use of structural imaging to study the progression of Alzheimer's disease. British Medical Bulletin, 52(3), pp.
Alzheimer’s disease is characterised as a dementia with the presence of amyloid plaques and neurofibrillary tangles which leads to neuronal cell death (Hardy & Higgins, 1992). The most major symptom shown in Alzheimer’s disease is the degeneration of cognitive function (memory, reasoning, attention, language etc.) and it is crucial to diagnose Alzheimer’s disease in the early clinical stages where the pathological damage isn’t too serious so to prevent further damage occurring at a rapid rate (Amieva, et al., 2008). Clinical diagnosis and research of Alzheimer’s disease use Braak staging to classify …show more content…
B. et al., 2010. The clinical use of structural MRI in Alzheimer disease. Nature Reviews Neurology, 6(2), pp. 67-77.
Hardy, J. A. & Higgins, G. A., 1992. Alzheimer's disease: the amyloid cascade hypothesis. Science, 256(5054), p. 184.
Johnson, K. A., Fox, N. C., Sperling, R. A. & Klunk, W. E., 2012. Brain Imaging in Alzheimer Disease. Cold Spring Harbor Perspectives in Medicine, 2(4).
Lee, B. C. P., Mintun, M., Buckner, R. L. & Morris, J. C., 2003. Imaging of Alzheimer's Disease. Journal of Neuroimaging, 13(3), pp. 199-214.
McGeer, P. L. et al., 1986. Comparison of PET, MRI and CT with pathology in a proven case of Alzheimer's disease. Neurology, Volume 36, pp. 1569-1574.
Mosconi, L. et al., 2008. Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias. Journal of Nuclear Medicine, 49(3), pp. 390-398.
Mueller, S. G. et al., 2005. Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimer's & Dementia, 1(1), pp. 55-66.
Smith, A. D. & Jobst, K. A., 1996. Use of structural imaging to study the progression of Alzheimer's disease. British Medical Bulletin, 52(3), pp.