Description
In 1932, amphetamine first emerged as an over-the-counter drug. Amphetamine was widely embraced by military personnel, politicians, pilots, physicians, writers, students, and professors (Moore, 2010). Amphetamines are chemicals that alter the way the body works and can make the body work faster than usual. This drug stimulates …show more content…
Amphetamines are substrates for carriers linked with the uptake of the biogenic amines dopamine (DA), norepinephrine (NE), and serotonin (5-HT) (Kehr et al., 2011). The dopamine and the serotonin release from storage vesicles, avoid the uptake into vesicles, and making them more freely available for inverse transport. Both dopamine and the serotonin are promoted by amphetamines. An increased neurotransmission of dopamine occurs by the acute action of the amphetamines. Amphetamines are also increased because of the release of glutamate. Glutamate possibly contributes to the neurotoxicity profiles of these drugs (Kehr et al.,