Analysis Of Huntington's Disease

Huntington’s disease is an autosomal-dominant neurodegenerative disorder that may arise from the dysfunction of the ubiquitin-proteasome system. It is caused by a single defective gene on chromosome 4, more specifically, the abnormal expansion of a polyglutamine tract located in the N-terminus of huntingtin. The defective gene codes the blueprint for huntingtin—this protein can cause alterations in brain activity that produces abnormal involuntary movements, a severe decline in both thinking and reasoning skills, irritability, depression as well as a various number of other mood changes. Unlike Parkinson’s or Alzheimer’s disease, Huntington’s disease affects people who are younger in age. It shows the most prevalence in white populations, affecting