Analysis Of Sodium Alginate
How did the amount of Sodium Citrate, an anticoagulant, added to a Calcium Chloride solution affect the volume of the clots formed when a sodium alginate solution, a blood simulation, was introduced?
Mackenzie Keesor (Fall Semester 2017-2018)
Purpose
The purpose of this experiment was to observe the differences in the formation of simulated blood clots when different amounts of sodium citrate, an anticoagulant, was added to the coagulation process, which would help gain information about the process that could potentially be used to create medications for different blood clotting disorders.
Background Information
The average adult human body consists of approximately 4.7 to 5.5 liters of blood. This blood has many important functions. One …show more content…
The first treatment, mainly used in the case of an emergency is using “medicines called thrombolytics or ‘clot busters,’ that can quickly break up clots” (American Heart Association, “Prevention and Treatment of Excessive Blood Clotting”). The next treatment, used in non-emergency cases, is medication containing anticoagulants. Anticoagulants are blood thinners that prevent the formation of new blood clots. “Blood thinners are taken as either a pill, an injection under the skin, or through a needle or tube inserted into a vein” (American Heart Association, “Prevention and Treatment of Excessive Blood Clotting”). There are a few other treatments; However, they are short term and not as effective.
This experiment relates to the scientific study of inventing new medications. When completed, it could help the researcher gain information about the coagulation process. This information could potentially be used to create medications for different blood clotting disorders in the future.
Hypothesis
If the percentage of sodium citrate, an anticoagulant, added to a calcium chloride solution increases by 0.5 percent, then the volume of the clot formed will decrease by 50 …show more content…
The height of the ball formed was measured using the graph paper squares as a measuring device.
The graph paper was placed behind the ball so that your eye level was with the ball and the graph paper. Then, the number of lines the ball spanned were counted.
The height measurement was recorded in the data table.
Observations about the simulated blood clots were recorded in the data table.
Step 5 was repeated until 5 trials were completed using the solution of calcium chloride labeled No Sodium Citrate.
Step 5 was repeated until 5 trials were completed using the solution of calcium chloride labeled 0.5% Sodium Citrate.
Step 5 was repeated until 5 trials were completed using the solution of calcium chloride labeled 1% Sodium Citrate.
Step 5 was repeated until 5 trials were completed using the solution of calcium chloride labeled 1.5% Sodium Citrate.
The volume of each simulated blood clot was calculated using the formula for the volume of a semi-ellipsoid found on-line.
Volume of Simulated Blood Clots for Different Amounts of
Sodium Citrate
Percentage of Sodium Citrate
Trial #
Longest Diameter (mm)
Shortest Diameter (mm)
Height (mm)
Volume of Half Ellipsoid
Mackenzie Keesor (Fall Semester 2017-2018)
Purpose
The purpose of this experiment was to observe the differences in the formation of simulated blood clots when different amounts of sodium citrate, an anticoagulant, was added to the coagulation process, which would help gain information about the process that could potentially be used to create medications for different blood clotting disorders.
Background Information
The average adult human body consists of approximately 4.7 to 5.5 liters of blood. This blood has many important functions. One …show more content…
The first treatment, mainly used in the case of an emergency is using “medicines called thrombolytics or ‘clot busters,’ that can quickly break up clots” (American Heart Association, “Prevention and Treatment of Excessive Blood Clotting”). The next treatment, used in non-emergency cases, is medication containing anticoagulants. Anticoagulants are blood thinners that prevent the formation of new blood clots. “Blood thinners are taken as either a pill, an injection under the skin, or through a needle or tube inserted into a vein” (American Heart Association, “Prevention and Treatment of Excessive Blood Clotting”). There are a few other treatments; However, they are short term and not as effective.
This experiment relates to the scientific study of inventing new medications. When completed, it could help the researcher gain information about the coagulation process. This information could potentially be used to create medications for different blood clotting disorders in the future.
Hypothesis
If the percentage of sodium citrate, an anticoagulant, added to a calcium chloride solution increases by 0.5 percent, then the volume of the clot formed will decrease by 50 …show more content…
The height of the ball formed was measured using the graph paper squares as a measuring device.
The graph paper was placed behind the ball so that your eye level was with the ball and the graph paper. Then, the number of lines the ball spanned were counted.
The height measurement was recorded in the data table.
Observations about the simulated blood clots were recorded in the data table.
Step 5 was repeated until 5 trials were completed using the solution of calcium chloride labeled No Sodium Citrate.
Step 5 was repeated until 5 trials were completed using the solution of calcium chloride labeled 0.5% Sodium Citrate.
Step 5 was repeated until 5 trials were completed using the solution of calcium chloride labeled 1% Sodium Citrate.
Step 5 was repeated until 5 trials were completed using the solution of calcium chloride labeled 1.5% Sodium Citrate.
The volume of each simulated blood clot was calculated using the formula for the volume of a semi-ellipsoid found on-line.
Volume of Simulated Blood Clots for Different Amounts of
Sodium Citrate
Percentage of Sodium Citrate
Trial #
Longest Diameter (mm)
Shortest Diameter (mm)
Height (mm)
Volume of Half Ellipsoid