Langdon is summoned to Switzerland when it is discovered that an Illuminati brand was used to mark a dead man's chest. He meets Vittoria, the dead man's daughter, and Maximillian Kohler, the director of CERN, the Conseil Europyen pour la Recherche Nuclyaire, or European Council for Nuclear Research. Vittoria and her father have created a sample of antimatter, a highly unstable material, which has been stolen. They receive a call from the Vatican, stating that they have an unknown canister with CERN's logo on it. Langdon and Vittoria race to Rome, only to find that the canister endangers not only the physical structures there but also the College of Cardinals, who have gathered to elect a new Pope. Four cardinals are also missing.
The camerlengo, who is in charge of the Vatican until a new Pope is elected, receives a call from someone who claims that the Illuminati are behind all of the actions that night. He says that he will kill one of the missing cardinals each hour. Langdon and Vittoria think that if they can capture the killer, they can find the location of the antimatter. They find an ancient booklet which points to four sites called the Altars of Science. These sites form a pathway to the Church of Illumination, the Illuminati lair.
At each site, Langdon and Vittoria find one of the dead cardinals, branded