Angiogenesis
Introduction
1.1. ANGIOGENESIS Angiogenesis means for the growth of new capillary blood vessels in the body is an important natural process in the body used for healing and reproduction. The body controls angiogenesis by producing a precise balance of growth and inhibitory factors in healthy tissues. When this balance is disturbed, the result is either too much or too little angiogenesis. Abnormal blood vessel growth either excessive or insufficient is now recognized as a “common denominator” underlying many deadly and debilitating conditions including cancer, skin diseases, age related blindness, diabetic ulcers, cardiovascular disease, stroke and many others. Blood, carried in the vessels, delivers oxygen and nutrients to and removes waste products from the tissues. When new tissue is formed, blood vessel formation must occur as well. Thus, new tissue formed, for example, with the repair of wounds and the formation of the placenta during pregnancy are normal examples of intense new blood vessel formation (angiogenesis). The list of diseases that have angiogenesis as an underlying mechanism grows longer every year. [1] The essential role of angiogenesis in tumour growth was first proposed in 1971 by Judah Folkman, who described tumours as "hot and bloody. Angiogenesis is a multi-step process recruited for the formation of new blood vessels is one of the crucial processes for the growth, survival, proliferation and metastasis of tumours. Under normal conditions angiogenesis is virtually essential for cell reproduction, development and wound healing, etc. The process of neoangiogenesis involves endothelial cell proliferation, migration, and membrane degradation. The importance of angiogenesis for the growth and survival of tumours is widely appreciated. Numerous studies are being focused on the understanding of angiogenesis and the antiangiogenic agents have received significant attention because of their therapeutic implications especially in extending the life
1.1. ANGIOGENESIS Angiogenesis means for the growth of new capillary blood vessels in the body is an important natural process in the body used for healing and reproduction. The body controls angiogenesis by producing a precise balance of growth and inhibitory factors in healthy tissues. When this balance is disturbed, the result is either too much or too little angiogenesis. Abnormal blood vessel growth either excessive or insufficient is now recognized as a “common denominator” underlying many deadly and debilitating conditions including cancer, skin diseases, age related blindness, diabetic ulcers, cardiovascular disease, stroke and many others. Blood, carried in the vessels, delivers oxygen and nutrients to and removes waste products from the tissues. When new tissue is formed, blood vessel formation must occur as well. Thus, new tissue formed, for example, with the repair of wounds and the formation of the placenta during pregnancy are normal examples of intense new blood vessel formation (angiogenesis). The list of diseases that have angiogenesis as an underlying mechanism grows longer every year. [1] The essential role of angiogenesis in tumour growth was first proposed in 1971 by Judah Folkman, who described tumours as "hot and bloody. Angiogenesis is a multi-step process recruited for the formation of new blood vessels is one of the crucial processes for the growth, survival, proliferation and metastasis of tumours. Under normal conditions angiogenesis is virtually essential for cell reproduction, development and wound healing, etc. The process of neoangiogenesis involves endothelial cell proliferation, migration, and membrane degradation. The importance of angiogenesis for the growth and survival of tumours is widely appreciated. Numerous studies are being focused on the understanding of angiogenesis and the antiangiogenic agents have received significant attention because of their therapeutic implications especially in extending the life
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