Antidepressant Case Study
Hello Dr. Brown,
Thank you for your reply. I do believe that it is a challenge for physicians to decide which antidepressant would produce optimal outcome for their patients. Some patients may only need one specific drug, while others may need a combination of antidepressants to manage the disease. Hence, the results from clinical studies/research are of importance to provide medical practitioners information that are relevant to their practice.
Now I will try to answer your question, “Given the numerous medications available for the treatment of depression, what are some factors that must be taken into consideration when determining which would be most suitable for a certain individual?”
There is little difference in antidepressant effectiveness, …show more content…
However, physiologic changes associated with aging, such as decreased hepatic metabolism and decreased renal function, decreases medication tolerance in older adults. Hyponatremia is seen in about 10% of elderly taking antidepressants, particularly with selective serotonin reuptake inhibitors (SSRIs) (Weis, 2011). Furthermore, the increased permeability of the blood-brain barrier, as well as the decrease in cholinergic receptors, increases anticholinergic symptoms which is not well tolerated by the elderly (Drug.com, n.d). Likewise, some studies suggest that antidepressants may promote suicidal thoughts in vulnerable children and adolescents (Nischal, Tripathi, Nischal, &Trivedi, 2012; McCain, 2009). Accordingly, prescribers may indicate switching from one antidepressant to adequately treat the disease and manage unacceptable adverse …show more content…
However, one of their common side-effect is sexual dysfunction. Sexual dysfunction may impact on the person’s emotional and psychological state, as well recovery, which may result to noncompliance with antidepressant treatment and a higher chance for recurrence of symptoms (Higgins, Nash & Lnych, 2010). Hence, in the United States, bupropion is used in combination of SSRIs to reduce its sexual side effects (Koenig & Thase, 2009). Furthermore, tricyclics antidepressants, due to its lack of selectivity, the use of these drugs has been limited. Their negative adverse effects involving the autonomic nervous system, and the cardiovascular system, as well as sedation has led to decreased tolerability (Ciccone, 2016). Hence, to avoid treatment failure, tolerability to adverse effects should be considered to improve adherence to
Thank you for your reply. I do believe that it is a challenge for physicians to decide which antidepressant would produce optimal outcome for their patients. Some patients may only need one specific drug, while others may need a combination of antidepressants to manage the disease. Hence, the results from clinical studies/research are of importance to provide medical practitioners information that are relevant to their practice.
Now I will try to answer your question, “Given the numerous medications available for the treatment of depression, what are some factors that must be taken into consideration when determining which would be most suitable for a certain individual?”
There is little difference in antidepressant effectiveness, …show more content…
However, physiologic changes associated with aging, such as decreased hepatic metabolism and decreased renal function, decreases medication tolerance in older adults. Hyponatremia is seen in about 10% of elderly taking antidepressants, particularly with selective serotonin reuptake inhibitors (SSRIs) (Weis, 2011). Furthermore, the increased permeability of the blood-brain barrier, as well as the decrease in cholinergic receptors, increases anticholinergic symptoms which is not well tolerated by the elderly (Drug.com, n.d). Likewise, some studies suggest that antidepressants may promote suicidal thoughts in vulnerable children and adolescents (Nischal, Tripathi, Nischal, &Trivedi, 2012; McCain, 2009). Accordingly, prescribers may indicate switching from one antidepressant to adequately treat the disease and manage unacceptable adverse …show more content…
However, one of their common side-effect is sexual dysfunction. Sexual dysfunction may impact on the person’s emotional and psychological state, as well recovery, which may result to noncompliance with antidepressant treatment and a higher chance for recurrence of symptoms (Higgins, Nash & Lnych, 2010). Hence, in the United States, bupropion is used in combination of SSRIs to reduce its sexual side effects (Koenig & Thase, 2009). Furthermore, tricyclics antidepressants, due to its lack of selectivity, the use of these drugs has been limited. Their negative adverse effects involving the autonomic nervous system, and the cardiovascular system, as well as sedation has led to decreased tolerability (Ciccone, 2016). Hence, to avoid treatment failure, tolerability to adverse effects should be considered to improve adherence to