Cajanus Cajan Case Study

Abstract: Cajanus cajan (L.) is one of the Pigeon pea cultivated in tropical and subtropical areas. It contains many fractions characterized by their bioactivity and efficacy to enhance biological activities. The aim of the present study was to fingerprinting the Cajanus cajan plant , then extract the flavonoids fraction (FFCC) with methanol extract, and assess the antimutagenic efficacy of the fraction extract to reduce genotoxicity induced by cyclophosphamide (CP) using chromosome aberrations, in mice bone-marrow cells and spermatocytes, and DNA damage by comet assay. Three doses from FFCC were orally administrated once for 24h at 50, 100 and 200 mg/kg b.wt simultaneously with CP at 20 mg/kg b.wt. The results revealed that the used doses of FFCC were safe in all experiments and their effect was normal compared to control group. Significant inhibition to CP-induced chromosomal aberrations in both somatic and germ cells was observed after concurrent administration of CP and different doses of
It is nontoxic edible herb, grain legume crop [1]. Cajanus cajan is full with bioactive components, which give it the potential to treat different diseases such as hepatitis, diabetes, measles and dysentery [2,3]. Also, the pigeon pea exhibits a fundamental role to act as anti-inflammatory, anti-biotic and anti-irritation agent [4,5]. In traditional medicine, the pigeon pea leaves extracts were used to kill worms and reduce pain [6], treat malaria, ulcers, injuries, and reduce hypercholesterolemia [7-9], sickle cell anemia, plasmodiasis, hepatic disorders, and hypoxic-ischemic brain [10-13]. The phytochemical research studies illustrated that the Cajanus cajan seeds possess numerous bioactive components including saponins, tannins, anthroquinone, triterpenoids, reducing sugars, alkaloids, phenols, and flavonoids