Cantilever Deflection Review
ANALYTICAL BIOCHEMISTRY
Analytical Biochemistry 363 (2007) 1–11 www.elsevier.com/locate/yabio
Review
Ultrasensitive biochemical sensors based on microcantilevers of atomic force microscope
Chengyin Wang b a,b
, Deyan Wang a, Yindao Mao a, Xiaoya Hu
a,b,*
a College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China Key Laboratory of Environmental Engineering and Monitoring of Jiangsu Province, Yangzhou, China
Available online 4 January 2007
Recent advances in microfabrication technologies have triggered new applications for micro/nanotools [1,2]. Micro/nanotechnology has become one of the most exciting forefront fields in analytical chemistry. A wide variety of micro/nanoscale materials of different sizes, shapes, and compositions are now available [3,4]. The huge interest in micro/nanomaterials is driven by their many desirable properties. In particular, the ability to tailor the size and structure and hence the properties of micro/nanomaterials offers excellent prospects for designing novel sensing systems and enhancing the performance of the biochemical analytical assay [5]. Over recent decades there has been a growing interest in parallel, miniaturized, automated, and cost-effective analytical techniques in applications such as environmental control, medical research, and pharmacological screening. Chemical and biochemical sensors have already demonstrated their suitability in these areas [6]. And as the development of the atomic force microscope (AFM),1 interest in microfabricated cantilevers has grown since 1986 [7]. By measuring the resonance frequency changes or cantilever bending due to additional mass
Corresponding author. Fax: +86 514 7975244. E-mail address: xyhu@yzu.edu.cn (X. Hu). 1 Abbreviations used: AFM, atomic force microscope; MC, microfabricated cantilever; PZT, lead zinconate titanate; BSA, bovine serum albumin. 0003-2697/$ - see front matter Ó 2006 Elsevier Inc. All rights reserved.
Analytical Biochemistry 363 (2007) 1–11 www.elsevier.com/locate/yabio
Review
Ultrasensitive biochemical sensors based on microcantilevers of atomic force microscope
Chengyin Wang b a,b
, Deyan Wang a, Yindao Mao a, Xiaoya Hu
a,b,*
a College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China Key Laboratory of Environmental Engineering and Monitoring of Jiangsu Province, Yangzhou, China
Available online 4 January 2007
Recent advances in microfabrication technologies have triggered new applications for micro/nanotools [1,2]. Micro/nanotechnology has become one of the most exciting forefront fields in analytical chemistry. A wide variety of micro/nanoscale materials of different sizes, shapes, and compositions are now available [3,4]. The huge interest in micro/nanomaterials is driven by their many desirable properties. In particular, the ability to tailor the size and structure and hence the properties of micro/nanomaterials offers excellent prospects for designing novel sensing systems and enhancing the performance of the biochemical analytical assay [5]. Over recent decades there has been a growing interest in parallel, miniaturized, automated, and cost-effective analytical techniques in applications such as environmental control, medical research, and pharmacological screening. Chemical and biochemical sensors have already demonstrated their suitability in these areas [6]. And as the development of the atomic force microscope (AFM),1 interest in microfabricated cantilevers has grown since 1986 [7]. By measuring the resonance frequency changes or cantilever bending due to additional mass
Corresponding author. Fax: +86 514 7975244. E-mail address: xyhu@yzu.edu.cn (X. Hu). 1 Abbreviations used: AFM, atomic force microscope; MC, microfabricated cantilever; PZT, lead zinconate titanate; BSA, bovine serum albumin. 0003-2697/$ - see front matter Ó 2006 Elsevier Inc. All rights reserved.