Cefotaxime Against Staphyloccus Au Reus
C4588
Description:
MIC: <0.1 μg/ml for S. pneumoniae
Cefotaxime is a cephalosporin antibiotic.
The cephalosporins, a class of β-lactam antibiotics originally derived from the fungus Acremonium, are indicated for the prophylaxis and treatment of infections caused by bacteria susceptible to this particular form of antibiotic.
In vitro: Previous studies found that the in-vitro activity of cefotaxime against Staphylococcus au reus has ranged from 0.8 g to 8 μg/ml with 50% of isolates inhibited by 2 μg/ml and 90% by 4 μg/ml. Moreover, it was found that methicillin resistant S. aureus were resistant to cefotaxime with MIC values above 64 μg/ml. The cefotaxime MICs against S. pneumoniae were found to be below 0.1 μg/ml, with 90% inhibited by 0.04 μg/ml. Cefotaxime has also been shown to have excellent activity against Haemophilus injluenzae, such as β-lactamase-containing strains [1]. …show more content…
Results indicated that combination therapy with cefotaxime and minocycline was distinctly more advantageous than therapy with the single antibiotic regimen for the treatment of severe Vibrio vulnificus infections
Description:
MIC: <0.1 μg/ml for S. pneumoniae
Cefotaxime is a cephalosporin antibiotic.
The cephalosporins, a class of β-lactam antibiotics originally derived from the fungus Acremonium, are indicated for the prophylaxis and treatment of infections caused by bacteria susceptible to this particular form of antibiotic.
In vitro: Previous studies found that the in-vitro activity of cefotaxime against Staphylococcus au reus has ranged from 0.8 g to 8 μg/ml with 50% of isolates inhibited by 2 μg/ml and 90% by 4 μg/ml. Moreover, it was found that methicillin resistant S. aureus were resistant to cefotaxime with MIC values above 64 μg/ml. The cefotaxime MICs against S. pneumoniae were found to be below 0.1 μg/ml, with 90% inhibited by 0.04 μg/ml. Cefotaxime has also been shown to have excellent activity against Haemophilus injluenzae, such as β-lactamase-containing strains [1]. …show more content…
Results indicated that combination therapy with cefotaxime and minocycline was distinctly more advantageous than therapy with the single antibiotic regimen for the treatment of severe Vibrio vulnificus infections