Cerebral Hypoxic Injury Case Study

A. Effects on catecholamine release and reduction of cerebral metabolic rate
Cerebral hypoxic injury is known to be associated with a massive catecholamine increase in central and peripheral norepinephrine concentrations are commonly seen with cerebral hypoxic injury. Catecholamines may impoverish outcome from cerebral ischemia, possibly by stimulating central _2-receptors (Figure 2.20).
Neuronal damages are results of icreased norepinephrine due to the elevation of metabolic demand and alteration of blood flow to surrounding ischemic tissue. The metabolites of norepinephrine further conduce to oxidative stress. During Ischemia, catecholamines signalize neurons that are more sensitive to glutamate leading to worsening damage of the central