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Characterization Of Microcephaly: The Flawless Operating System Of Humans

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Characterization Of Microcephaly: The Flawless Operating System Of Humans
Almighty Allah, due to His Mercy has given exceptional strength, talent and skill to humans and placed them at the top of Biological hierarchy. Flawless operating system of human was created by the Lord, yet genetic studies revealed that irregularities in genetic code and main control system may lead to death dealing disorders. Millions of unfortunate individuals suffering from different malformations authenticate the fact that nature has already performed extensive arbitrary mutagenesis on human brain, resulting in rich diversity of mutations that distort cortical development in distinct and surprising ways.(Walsh,1999)(70) Establishing the linkage association of genes that cause the genetic chaos, identification of the defective gene and …show more content…
Characterization of Microcephaly can be done by the finding that an individual has skull circumference below the expected mean for age and sex. The measurement is made from the forehead to occipital prominence at back of the head across the brow and should be the largest measurement possible2. Occipitofrontal head circumference (OFC) is considered to be the most frequent method for the diagnosis tool for Microcephaly (MCPH). Head circumference ranges from 2SD to 11SD below the mean in MCPH patients with very mild interfamilial difference in degree of microcephaly. (Mehmood et al., 2011) …show more content…
more than 10 % of prophase like cells in lymphocytes,fibroblasts and lymphoblast cell lines and this phenomenon is due to premature condensation in the early G2 phase. This premature entrance of cells into mitosis further indicated that mutated gene is involved in cell cycle regulation. (Neitzel at al.,2002). In some patients a high percentage of prophase like cells was also observed in combination with normal cell cycle continuance. Highly increased frequency of chromosomal breakage has been observed in some cases.(Tommerup et
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