Chemistry
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International Journal of Chemistry
Vol. 2, No. 2; August 2010
One-pot Preparation of β–amino Carbonyl Compounds by Mannich Reaction Using MgO/ZrO2 as Effective and Reusable Catalyst
Deepak.M. Nagrik (Corresponding author) Department of Chemistry, PLIT and MS Buldana-443001, M.S., India E-mail: dmnagrik@rediffmail.com D.M.Ambhore P.G.Department of Chemistry, Jijamata Mahavidyalaya Buldana-443001, M.S., India Manoj.B. Gawande (Corresponding author) Departamento de Química, Faculdade de Ciências and Tecnologia Quinta da Torre, 2829-516 Caparica, Portugal E-mail: mbgawande@yahoo.co.in, m.gawande@fct.unl.pt Abstract A new one-pot and efficient three-component condensation of aldehydes, ketones, and amines in the presence of MgO/ZrO2 as an inexpensive and effective catalyst for the synthesis of β-amino carbonyl compounds by Mannich reaction is described. The present methodology offers several advantages, such as good yields, short reaction times and a recyclable catalyst with a very easy work up. Keywords: Multi-component reaction, MgO/ZrO2, heterogeneous catalyst, β-amino Carbonyl compounds 1. Introduction The synthesis of natural molecules, pharmaceuticals and other nitrogenous biologically active compounds has long been a significant branch of organic synthesis. (B. List, 2002; 2000; R. O. Duthaler, 2003) The Mannich reaction provides one of the most basic and useful methods for the synthesis of such compounds. Multi-component reactions (MCRs) are important for the achievement of high levels of brevity and diversity. They allow more than two simple and flexible building blocks to be combined in practical, time-saving one-pot operations, giving rise to complex structures by simultaneous formation of two or more bonds, according to the domino principle. (Zhu, J., 2005) MCRs contribute to the requirements of an environmentally friendly process by reducing the number of synthetic steps, energy consumption and waste production. Researchers
International Journal of Chemistry
Vol. 2, No. 2; August 2010
One-pot Preparation of β–amino Carbonyl Compounds by Mannich Reaction Using MgO/ZrO2 as Effective and Reusable Catalyst
Deepak.M. Nagrik (Corresponding author) Department of Chemistry, PLIT and MS Buldana-443001, M.S., India E-mail: dmnagrik@rediffmail.com D.M.Ambhore P.G.Department of Chemistry, Jijamata Mahavidyalaya Buldana-443001, M.S., India Manoj.B. Gawande (Corresponding author) Departamento de Química, Faculdade de Ciências and Tecnologia Quinta da Torre, 2829-516 Caparica, Portugal E-mail: mbgawande@yahoo.co.in, m.gawande@fct.unl.pt Abstract A new one-pot and efficient three-component condensation of aldehydes, ketones, and amines in the presence of MgO/ZrO2 as an inexpensive and effective catalyst for the synthesis of β-amino carbonyl compounds by Mannich reaction is described. The present methodology offers several advantages, such as good yields, short reaction times and a recyclable catalyst with a very easy work up. Keywords: Multi-component reaction, MgO/ZrO2, heterogeneous catalyst, β-amino Carbonyl compounds 1. Introduction The synthesis of natural molecules, pharmaceuticals and other nitrogenous biologically active compounds has long been a significant branch of organic synthesis. (B. List, 2002; 2000; R. O. Duthaler, 2003) The Mannich reaction provides one of the most basic and useful methods for the synthesis of such compounds. Multi-component reactions (MCRs) are important for the achievement of high levels of brevity and diversity. They allow more than two simple and flexible building blocks to be combined in practical, time-saving one-pot operations, giving rise to complex structures by simultaneous formation of two or more bonds, according to the domino principle. (Zhu, J., 2005) MCRs contribute to the requirements of an environmentally friendly process by reducing the number of synthetic steps, energy consumption and waste production. Researchers