chemsitry assignment
Experiment 1: separating components of a counterfeit pharmaceutical
Aim Counterfeit pharmaceuticals are a big concern regarding the issue of medicines due to fake versions containing either the wrong ingredients or inaccuracy of the active ingredient which can cause toxicity issues in patients using these products. The aim of this experiment is to find if the percentage composition of the label (50% paracetamol, 40% aspirin and 10% sucrose) matches that of the percentage composition of the powder by following 10% ranges of each component in the powder. I am going to do this via a number of methods including vacuum filtration, heating, extraction and evaporation.
Experimental method:
The experiment was done in three parts: firstly the separation of sucrose, then the separation of Aspirin and the isolation of the unknown component.
1. Separation of Sucrose
Weight out and 3.00g of counterfeit pharmaceutical. Record the weight and transfer the sucrose to 100ml dry conical flask. Add 50ml of dichloromethane to the conical flask containing sucrose. Sucrose is usually liquid so adding organic solvent such as DCM will make the sucrose insoluble making it easy to collect the solid sucrose by vacuum filtration. Stir the mixture thoroughly containing the sucrose and DCM making sure the solid is dissolved. Filter the solid by vacuum filtration, saving the liquid for the next step into preweghed sample bag and filter paper. Weigh the sample bag containing the sucrose and record the mass of solid sucrose obtained by subtracting form the weight of sample bag and filter paper.
2. Separation of Aspirin
Transfer the filtrate form the separation of sucrose to 100ml separating funnel and extract it with two 30ml portions of 5% sodium bicarbonate solution to form sodium acetyl salycilate which
Aim Counterfeit pharmaceuticals are a big concern regarding the issue of medicines due to fake versions containing either the wrong ingredients or inaccuracy of the active ingredient which can cause toxicity issues in patients using these products. The aim of this experiment is to find if the percentage composition of the label (50% paracetamol, 40% aspirin and 10% sucrose) matches that of the percentage composition of the powder by following 10% ranges of each component in the powder. I am going to do this via a number of methods including vacuum filtration, heating, extraction and evaporation.
Experimental method:
The experiment was done in three parts: firstly the separation of sucrose, then the separation of Aspirin and the isolation of the unknown component.
1. Separation of Sucrose
Weight out and 3.00g of counterfeit pharmaceutical. Record the weight and transfer the sucrose to 100ml dry conical flask. Add 50ml of dichloromethane to the conical flask containing sucrose. Sucrose is usually liquid so adding organic solvent such as DCM will make the sucrose insoluble making it easy to collect the solid sucrose by vacuum filtration. Stir the mixture thoroughly containing the sucrose and DCM making sure the solid is dissolved. Filter the solid by vacuum filtration, saving the liquid for the next step into preweghed sample bag and filter paper. Weigh the sample bag containing the sucrose and record the mass of solid sucrose obtained by subtracting form the weight of sample bag and filter paper.
2. Separation of Aspirin
Transfer the filtrate form the separation of sucrose to 100ml separating funnel and extract it with two 30ml portions of 5% sodium bicarbonate solution to form sodium acetyl salycilate which