Introduction
1. What organs are involved in hormonal control of male reproductive functions? Hypothalamus, Anterior pituitary and testis. Hormonal Control of Male Reproductive Functions 2. a. Describe gonadotropin releasing hormone (GnRH) production. @ puberty the hypothalamus secretes GnRH which stimulates anterior pituitary secretion of LH & FSH b. Describe GnRH affects on the male anterior pituitary. GnRH stimulates the anterior pituitary to increase secretions of LH & FSH 3. What affect does luteinizing hormone (LH) have on the testes? It stimulates Leydig cells to secrete the hormone testosterone. 4. a. What affect does testosterone and FSH have on the testes? Sertoli cells produce ABP that binds & maintains increased levels of testosterone. b. What affect is the affect of androgen-binding protein? ABP binds & maintains the high levels of testosterone near the spermatogonia cells.
5. If you haven’t summarized it already, what affect does testosterone have on spermatogenesis? Testosterone stimulates the final stages of spermatogenesis
6. How do testosterone and DHT affect male prenatal development? Testosterone stimulates the male pattern of reproductive system ducts and descent of the testes. DHT stimulates the development of the male external genitals.
7. Describe inhibin secretion. From where? Why? Effect? Sertoli cells release inhibin which reduces FSH secretions, thereby regulating (decreasing) of the rate of spermatogenesis.
8. Explain the negative feedback loop that regulates spermatogenesis at homeostatic levels. Testosterone acts in a negative feedback manner on anterior pituitary gonadotrophs to suppress the secretion of LH. The negative