Crohn's Disease

Crohn’s disease (CD) is a chronic inflammatory disease of the intestines that causes ulceration in the small and large intestines, but affects the digestive system between the mouth and the anus. Once the disease begins, it tends to be a chronic, recurrent condition with periods of remission and disease exacerbation. The disease tends to be more common in relatives of patients with Crohn’s disease. Crohn’s disease affects males and females at the same rate, normally between the ages of 10 and 30 y/s. Jewish people form Eastern European have a higher chance of CD. Genetic susceptibility and altered immunologic response to the normal bowel flora are the risk factors of CD. In addition, “Increased suppressor T cell activity, alterations in immunoglobulin A (IgA) production, macrophage activation, luminal flora, antigens, and susceptibility genes are factors associated with Crohn disease” (McCance & Huether, 2012, p.909). Overall, this paper is focusing on the steps of Crohn’s disease to cause ulcers in the small intestine, colon or both, their symptoms, their complications and pathogenic changes.
To begin, there are five different types of Crohn’s disease are to be known. 1. Lleocolotis affects the small intestine (ileum and colon) 2.Lieitis, it is also affecting the ileum same as lleocolotis. 3. Gastroduodenal Crohn’s disease, affecting the stomach and duodenum (first part of small intestine) 4. Jejunoileitis, affects the jejunum, which is the upper half of the small intestine. And 5. Crohn’s colitis, which affect only the colon. But some people do have more than one area of the digestive track is affected. Crohn’s disease is known as “skip lesions” because the inflammation affects sections of the intestine, but not others (McCance & Huether, 2012, p.909).
Crohn's disease causes small, scattered, shallow, crater-like ulcerations (erosions) on the inner surface of the bowel. Within time, the erosions become deeper and larger, after becoming true ulcers it