Crohn's Disease: Is It Hereditary?

Headline: Crohn’s Disease: Is It Hereditary?

Keywords: Crohn’s Disease, colon, genetic disorder, chromosome

Page Description: Crohn’s disease is a disease in which inflammation, thickening and swelling of gastrointestinal occur. It also increases the risk of colon cancer in patients. It is also known as a complex genetic disorder. Chromosome 5 and 10 has been identified to be linked with this genetic disorder.

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Crohn’s Disease

Crohn’s disease is a disease in which one or more parts of gastrointestinal tract gets swollen, inflamed and thickened. Colon and last part of small bowel are most commonly affected with Crohn’s disease. If the Crohn’s disease affects only colon, symptoms may look similar to that of ulcerative colitis as both the diseases affect the colon with similar symptoms. Ulcerative colitis is effectively treated with removal of colon. Crohn’s disease which only affects colon is termed as Crohn’s colitis.

Diagnose
Colonoscopy is used to diagnose Crohn’s disease.
In colonoscopy, a narrow tube is inserted into lower bowel through anal canal. Using this tube, specialist observes the colon lining. The tube has a small camera with a light source to look at the colon lining. Colonoscopy is considered best to diagnose direct visualization of colon. Patients of Crohn’s disease also have the risk of developing colon cancer. Radiological tests are performed in case the small abnormalities in colon are difficult to detect through colonoscopy.

Genetic
Cause

Causes of Crohn’s disease are not known but may be due to the genetic disorder. It is considered that it may be result of genetic variations leading to this genetic disorder. Environmental factors together with genetic disorder are found to be the major causes. Rather it is the first such genetic disorder which has been understood in detail about the relationship between environmental factor and immune system. It is also known as a complex gene disorder as it involves multiple genes contributing the disease.

In a recent research conducted on this genetic disorder has identified that damage to the human gene NOD2 is associated with this disease. People with greater genetic component are likely to develop this genetic disorder at an early stage as compared to those with a less genetic component. Scientists have found that this genetic disorder is also linked with other diseases.

To understand this genetic disorder in more detail, chromosome and gene should be talked about. Humans have 23 chromosome pairs. Some parts of chromosome 5 and chromosome 10 have been linked with Crohn’s disease. Scientists have found changes in around 30 genes on the chromosome 5 and chromosome 10 that increase the risk of development of this genetic disorder. Variations in some regions of chromosome 5 and chromosome 10 appear to contribute to Crohn’s disease risk. IBD5 locus is one area on chromosome 5 that contains several genetic variations. Other regions found on chromosome 5 and chromosome 10 has no genes at all. These are called gene deserts and may contribute to this genetic disorder. }

Author: I am a Freelance Content Writer and have been writing different types of content in various domains viz. technical writing, non-technical writing and medical writing.

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