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Pentraxin 3 is a protein in humans is encoded by the PTX3 gene. Pentraxin 3 is a member of the pentraxin taxon. This super family characterised by cyclic multimeric structure. PTX3 is produced and released by many cell sorts, specifically by mononucleate phagocytes, nerve fibre cells, fibroblasts and epithelium cells in response to primary inflammatory signals. PTX3 binds with high affinity to the complement element C1q, the living thing matrix element TNFα induced protein 6 and chosen microorganisms, as well as Aspergillus fumigatus and genus Pseudomonas aeruginosa. PTX3 activates the classical pathway of complement activation and facilitates infectious agent recognition by macrophages and DCs.
The transcribed PTX3 is 381 amino acids long, features a expected mass