DSC Thermogram Of Mirtazapine Hydrochloride Lab Report

modes associated with them,such as symmetric and asymmetric stretches,bends, rocks, and tortional modes. For MRZ, the C-H stretching Vibrations are observed at 3057, 3043, 3016 and 2999 cm-1. The asymmetric and symmetric stretching bands of CH2 are observed in the range from 2900 to 2700 cm-1 and this stretching band is mainly coupled with the CH3 stretching vibration. Mirtazapine has only one CH3 group. The C-H stretching vibrations of methyl are observed between 3000 and 2900 cm-1. A methyl group attached to a nitrogen atom gives rise to a band in the region 2800-2780 cm-1.These vibrations are observed at 2966 and 2856 cm-1.
The C-C stretching modes of phenyl group are expected in the range of 1650-1200 cm-1 .Bands at 1587,1566 and 1497
Figure 4.3: DSC Thermogram of Chitosan.
The thermogram of pure Chitosan shows dehydration at 78.7 ° C and the second thermal event may be related to the decomposition of amine (GlcN) units with correspondent exothermic peak at 295° C. Reported melting point of Chitosan is 101-200 ° C .The heating rate of 10° C/min was used. Also the starting of exothermic peak at 296° C confirms the degree of deacetylation of the chitosan as >75% which is desirable for nose to brain delivery [8]. Figure 4.4 DSC Thermogram of Sodium TPP Kouchak M. et al, reported the endothermic peaks of TPP at 120° C and at 210° C.[9] The obtained thermogram of pure Sodium Tripolyphosphate shows melting endotherm at 118° C and 197.2 °C which is comparable to the reported peaks in literature. This confirms the authenticity of TPP utilizing DSC. Figure 4.5 DSC Thermogram of Poloxamer
et al reported the melting peak of poloxamer 188 at 55.99° C.[10] The obtained thermogram of pure Poloxamer 188 shows sharp melting endotherm at 52.15° C, proving the authenticity of the excipient as Poloxamer 188. Figure 4.6 DSC Thermogram of physical mixture of mirtazapine and excipients
The DSC thermogram of the physical mixture of Drug and excipients shows the sharp endotherm at 112.88°C which is comparable to the endothermic peak of the pure drug obtained at 114.91 °C. Table 4.5 shows the individual melting points of the drugs and excipients and the endotherm obtained on analysis of the physical mixture.
Table 4.5 Melting points of drug and excipients
Excipient Drug Chitosan Na TPP Poloxamer 188 Physical