Transmission of DNA and
RNA
Western Governors University
DNA Replication
DNA and the function of Ligase
mRNA in Transcription and Translation
Death by Inhibition: RNA polymerase and the Death
Cap Mushroom
Ingestion of the Death Cap Mushroom
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No Presenting symptoms for 48 hours
The deadly toxin is alpha-amanitin
Amanitin has a great attraction to RNA polymerase
It’s toxin blocks RNA polymerase from functioning
Without RNA polymerase no proteins can be made
If no proteins are made cells can no longer function
(Santi, et al., 2012)
If you took RNA polymerase out of the equation?
Human cells use RNA polymerase to make a template of a cell’s
DNA. It is one of the first steps …show more content…
mRNA, if available, goes on to the translation phase and is read by tRNA. In the reading of the mRNA pattern, tRNA matches the correct amino acid to that specific pattern. The amino acids are read and placed three at a time to match the mRNA codon. From these codon of amino acids, polypeptides are formed with the help of the cell’s ribosome. In turn, these polypeptides form to make proteins. (Hudon-Miller, 2012)
What’s the big deal about protein?
Proteins, the performers of the cell, cause action at all levels of cellular functioning. At the cellular level protein is needed to reproduce that cell, for cell structure and functioning. Proteins are also used as enzymes to begin other biochemical functions that affect everything from immunity to electrolyte balance. The liver’s function has decreased because the proteins needed to make it’s cells work have been blocked by alpha-amanitin’s ability to stop protein production simply by blocking the function of RNA polymerase. These proteins are so important that without them you die as they destroy first your body’s filters, the liver and the kidneys. (Hudon-Miller, 2012; Santi, et al.,