drug study of morphine sulfate
MORPHINE SULFATE
(mor’feen)
Brand Names: Astramorph PF, Avinza, DepoDur, Duramorph, Epimorph , Kadian, MSIR, MS Contin, Oramorph SR, Roxanol, RMS, Statex
Classifications: central nervous system (cns) agent; analgesic; narcotic (opiate) agonist
Pregnancy Category: B (D in long-term use or high dose)
Controlled Substance: Schedule II
Contents
1 Availability
2 Actions of Morphine Sulfate
3 Therapeutic Effects
4 Uses
5 Contraindications
6 Cautious Use
7 Route & Dosage
8 Administration
9 Adverse Effects ( 1%)
10 Diagnostic Test Interference
11 Interactions
12 Pharmacokinetics
13 Nursing Considerations
13.1 Assessment & Drug Effects
13.2 Patient & Family Education
Availability
10 mg, 15 mg, 30 mg tablets/capsules; 15 mg, 20 mg, 30 mg, 60 mg, 100 mg, 120 mg, 200 mg controlled release tablets/capsules; 10 mg/2.5 mL, 10 mg/5 ml, 20 mg/mL, 20 mg/5 mL, 30 mg/1.5 mL, 100 mg/5 mL oral solution; 0.5 mg/mL, 1 mg/mL, 2 mg/mL, 4 mg/mL, 5 mg/mL, 8 mg/mL, 10 mg/mL, 15 mg/mL, 25 mg/mL, 50 mg/mL injection; 10 mg/mL, 15 mg/1.5 mL, 20 mg/2 mL extended-release lysosomal injection; 5 mg, 10 mg, 20 mg, 30 mg suppositories
Actions of Morphine Sulfate
Natural opium alkaloid with agonist activity by binding with the same receptors as endogenous opioid peptides.
Narcotic agonist effects are identified with 3 types of receptors: Analgesia at supraspinal level, euphoria, respiratory depression and physical dependence; analgesia at spinal level, sedation and miosis; and dysphoric, hallucinogenic and cardiac stimulant effects.
Therapeutic Effects
Controls severe pain; also used as an adjunct to anesthesia.
Uses
Symptomatic relief of severe acute and chronic pain after nonnarcotic analgesics have failed and as preanesthetic medication; also used to relieve dyspnea of acute left ventricular failure and pulmonary edema and pain of MI.
Contraindications
Hypersensitivity to opiates; increased intracranial pressure; convulsive disorders; acute alcoholism; acute bronchial
(mor’feen)
Brand Names: Astramorph PF, Avinza, DepoDur, Duramorph, Epimorph , Kadian, MSIR, MS Contin, Oramorph SR, Roxanol, RMS, Statex
Classifications: central nervous system (cns) agent; analgesic; narcotic (opiate) agonist
Pregnancy Category: B (D in long-term use or high dose)
Controlled Substance: Schedule II
Contents
1 Availability
2 Actions of Morphine Sulfate
3 Therapeutic Effects
4 Uses
5 Contraindications
6 Cautious Use
7 Route & Dosage
8 Administration
9 Adverse Effects ( 1%)
10 Diagnostic Test Interference
11 Interactions
12 Pharmacokinetics
13 Nursing Considerations
13.1 Assessment & Drug Effects
13.2 Patient & Family Education
Availability
10 mg, 15 mg, 30 mg tablets/capsules; 15 mg, 20 mg, 30 mg, 60 mg, 100 mg, 120 mg, 200 mg controlled release tablets/capsules; 10 mg/2.5 mL, 10 mg/5 ml, 20 mg/mL, 20 mg/5 mL, 30 mg/1.5 mL, 100 mg/5 mL oral solution; 0.5 mg/mL, 1 mg/mL, 2 mg/mL, 4 mg/mL, 5 mg/mL, 8 mg/mL, 10 mg/mL, 15 mg/mL, 25 mg/mL, 50 mg/mL injection; 10 mg/mL, 15 mg/1.5 mL, 20 mg/2 mL extended-release lysosomal injection; 5 mg, 10 mg, 20 mg, 30 mg suppositories
Actions of Morphine Sulfate
Natural opium alkaloid with agonist activity by binding with the same receptors as endogenous opioid peptides.
Narcotic agonist effects are identified with 3 types of receptors: Analgesia at supraspinal level, euphoria, respiratory depression and physical dependence; analgesia at spinal level, sedation and miosis; and dysphoric, hallucinogenic and cardiac stimulant effects.
Therapeutic Effects
Controls severe pain; also used as an adjunct to anesthesia.
Uses
Symptomatic relief of severe acute and chronic pain after nonnarcotic analgesics have failed and as preanesthetic medication; also used to relieve dyspnea of acute left ventricular failure and pulmonary edema and pain of MI.
Contraindications
Hypersensitivity to opiates; increased intracranial pressure; convulsive disorders; acute alcoholism; acute bronchial