Elevated Intraocular Pressure
Intraocular pressure (IOP) variations after switching from latanoprost to bimatoprost in open-angle glaucoma patients
Introduction:
In the world glaucoma is the second leading cause of irreversible. It is a optic neuropathy disease characterized by loss of retinal ganglion cells and axons resulting in a characteristic and distinctive appearance of optic disc, associated with loss of visual function. Elevated intraocular pressure (IOP) is the main risk factor and the only one that can be modified using available therapies. Latanoprost is a F2-alpha prostaglandin analog designed to reduce the IOP in patients with glaucoma and ocular hypertension. Whereas, Bimatoprost is an ocular hypotensive drug that belongs to a family of fatty acid amides called prostamides. Its mechanism of action includes the reduction of tonographic resistance to aqueous humor outflow and an increase of the outflow rate through the uveoescleral pathway. When these 2 drugs are compared IOP reduction tended to be …show more content…
Method:
Forty-one patients on latanoprost who showed a peak IOP increase of at least 15% relative to the peak IOP measured during the previous water drinking test (WDT) were included in this study. In these patients treatment was changed to 0.01% bimatoprost with no washout period in between. Baseline, peak, and IOP measurements at each time point (15, 30, and 45 min) during all 3 WDT sessions (WDT1, WDT2 and WDT3) were measured. Computerized statistical analyses were performed where P <0.001).
• The mean IOP at each time point during the WDT sessions was significantly different between WDT1 and WDT2 and between WDT2 and WDT3. Fig 1 Figure 1: The mean intraocular pressure at each time point during the water drinking
Introduction:
In the world glaucoma is the second leading cause of irreversible. It is a optic neuropathy disease characterized by loss of retinal ganglion cells and axons resulting in a characteristic and distinctive appearance of optic disc, associated with loss of visual function. Elevated intraocular pressure (IOP) is the main risk factor and the only one that can be modified using available therapies. Latanoprost is a F2-alpha prostaglandin analog designed to reduce the IOP in patients with glaucoma and ocular hypertension. Whereas, Bimatoprost is an ocular hypotensive drug that belongs to a family of fatty acid amides called prostamides. Its mechanism of action includes the reduction of tonographic resistance to aqueous humor outflow and an increase of the outflow rate through the uveoescleral pathway. When these 2 drugs are compared IOP reduction tended to be …show more content…
Method:
Forty-one patients on latanoprost who showed a peak IOP increase of at least 15% relative to the peak IOP measured during the previous water drinking test (WDT) were included in this study. In these patients treatment was changed to 0.01% bimatoprost with no washout period in between. Baseline, peak, and IOP measurements at each time point (15, 30, and 45 min) during all 3 WDT sessions (WDT1, WDT2 and WDT3) were measured. Computerized statistical analyses were performed where P <0.001).
• The mean IOP at each time point during the WDT sessions was significantly different between WDT1 and WDT2 and between WDT2 and WDT3. Fig 1 Figure 1: The mean intraocular pressure at each time point during the water drinking