Embryology of Heart
Development of the heart
October -08 -12
TUBE FORMATION
• 15 days after conception
○ Begins as flat sheet of mesodermal cells (cells of the mesoderm layer in an embryo)
• Day 18-20
○ The cells form a horse -shoe shape (cardiogenic region)
○ Angiogenic cell clusters coalesce to form right and left endocardial tubes
• Day 21
○ Two endocardial tubes are completely fused
• Day 22
○ Heart begins beating
• Day 23
○ Heart tube forms constrictions prior to looping
The first indication of heart development is around day 16- 19. Clusters of angiogenetic cells form a
"horseshoe- shaped" cluster anterior and lateral to the brain plate.
Following cardiac mesoderm involution during gastrulation, the two endocardial tubes fuse along the embryonic midline. The heart starts to beat at day 22, but the circulation does not start until days
27 to 29. The single tubular heart develops many constrictions outlining future structures.
Prior to looping the heart tubes forms constrictions defining separate components of the heart, these are
(cranial to caudal): Bulbus Cordis , Ventricle and
Atrium. The primitive atrium is still paired and connects caudally to the paired sinus venosus. The heart tube will bend ventrally, caudally and slightly to the right.
At this stage the paired sinus venosus extend laterally and give rise to the sinus horns. As the cardiac looping is developing the paired atria form a common chamber and move into the pericardial sac.
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LOOPING
• Day 21
○ Linear heart tube bends toward right side
• Day 22
○ Chambers begin to form
○ Left ventricle is expands to a large size and is spherical
Formed by most of the heart tube
○ Right ventricle is small
Anterior to left ventricle
• Day 26
○ As the heart continues to loop, the right and left ventricle arrange themselves so that they are beside one another
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beside one another
○
○ Atria are arranged side by side on
October -08 -12
TUBE FORMATION
• 15 days after conception
○ Begins as flat sheet of mesodermal cells (cells of the mesoderm layer in an embryo)
• Day 18-20
○ The cells form a horse -shoe shape (cardiogenic region)
○ Angiogenic cell clusters coalesce to form right and left endocardial tubes
• Day 21
○ Two endocardial tubes are completely fused
• Day 22
○ Heart begins beating
• Day 23
○ Heart tube forms constrictions prior to looping
The first indication of heart development is around day 16- 19. Clusters of angiogenetic cells form a
"horseshoe- shaped" cluster anterior and lateral to the brain plate.
Following cardiac mesoderm involution during gastrulation, the two endocardial tubes fuse along the embryonic midline. The heart starts to beat at day 22, but the circulation does not start until days
27 to 29. The single tubular heart develops many constrictions outlining future structures.
Prior to looping the heart tubes forms constrictions defining separate components of the heart, these are
(cranial to caudal): Bulbus Cordis , Ventricle and
Atrium. The primitive atrium is still paired and connects caudally to the paired sinus venosus. The heart tube will bend ventrally, caudally and slightly to the right.
At this stage the paired sinus venosus extend laterally and give rise to the sinus horns. As the cardiac looping is developing the paired atria form a common chamber and move into the pericardial sac.
New Section 1 Page 1
LOOPING
• Day 21
○ Linear heart tube bends toward right side
• Day 22
○ Chambers begin to form
○ Left ventricle is expands to a large size and is spherical
Formed by most of the heart tube
○ Right ventricle is small
Anterior to left ventricle
• Day 26
○ As the heart continues to loop, the right and left ventricle arrange themselves so that they are beside one another
New Section 1 Page 2
beside one another
○
○ Atria are arranged side by side on