Endocrine Signaling Report

Through endocrine signaling, the signaling molecule or hormone is produced by a gland and discharged into the blood where it travels until it reaches certain blood cells distant from its place of origin on which it exerts its action. This is a long distance communication process. The signaling molecule is mainly of protein origin, although there is also a varied range of steroidal hormones.

(ENDOCRINE SIGNALLING: Image from University of Kent https://moodle.kent.ac.uk/external/mod/book/view.php?id=2396&chapterid=78) Pick a representative signal molecule from the pathway you have chosen and indicate its function, the type of cell in which it is made and the specific manner in which it acts as a signalling molecule, including the receptor
It interacts with:
1) Steroid 11beta-monooxygenase, an enzyme that catalyzes the chemical reaction ("Steroid 11Β-Hydroxylase")
2) 3beta-hydroxy-Delta5-steroid dehydrogenase, this gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol ("3β-Hydroxysteroid dehydrogenase", 2017).
3) Corticosteroid 11-beta-dehydrogenase isozyme, Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone ("Corticosteroid 11-beta-dehydrogenase isozyme 2", 2017)
Click on the shape that contains your molecule of interest (or its receptor) (this will redirect you to a page that lists the signaling pathways in which that molecule is involved and any diseases associated with it.
Take a note of the names of at least three other pathways indicated on this page and comment on whether your molecule is linked with any diseases. (If there is no disease association there will be no entry in the
Metabolic pathways map04080 Neuroactive ligand-receptor interaction map04960 Aldosterone-regulated sodium reabsorption map04976 Bile secretion map05200 Pathways in cancer map05215 Prostate cancer map07225 Glucocorticoid and meneralocorticoid receptor