Exam 2008 Answer Key
BIOE 301/362 Name:
Exam 2
March 13, 2008
The exam consists of 10 questions. Show all work to receive credit. Clearly organize your work and draw a box around your final answers. NEATNESS COUNTS! Good Luck!
Problem 1 (5):
Problem 2 (18):
Problem 3 (12):
Problem 4 (15):
Problem 5 (8):
Problem 6 (12):
Problem 7 (12):
Problem 8 (18):
Extra Credit (4):
Total (100):
PROBLEM 1: Development of technology (5 points total)
Eureka! You have just created what could be an HIV vaccine. Describe the steps which you must undertake before you can obtain FDA approval to market this vaccine.
Pre clinical testing in animals
Phase I testing in healthy volunteers to monitor safety
Phase II testing to monitor safety and efficacy
Phase III testing to monitor safety and efficacy
FDA submission for approval to market
PROBLEM 2: Multiple choice. 3 pts each (18 points total).
a. Bordetella pertussis and Influenza A virus are examples of respiratory pathogens; bacterial and viral, respectively. As such, they can both:
Reproduce extracellularly, in saliva and lung fluids
Be killed with antibiotics
Reproduce inside lung cells
Cause inflammation and coughing
Answer:d (viruses can’t reproduce outside cells, or be killed with antibiotics, bordatella can’t reproduce inside lung cells, so the only common thing between them is causing inflammation)
b. If a pathogen penetrates the skin barrier, which of the following action (s) will your immune system take as a first step to fight infection:
Activate B-cells to generate antibodies against it
Activate T-cell responses to kill infected cells
Launch macrophages and inflammatory molecules to signal infection
Release platelets to drive coagulation and prevent the pathogen from entering the blood flow
Answer: c (innate imunity-macrophages and inflammation-
Exam 2
March 13, 2008
The exam consists of 10 questions. Show all work to receive credit. Clearly organize your work and draw a box around your final answers. NEATNESS COUNTS! Good Luck!
Problem 1 (5):
Problem 2 (18):
Problem 3 (12):
Problem 4 (15):
Problem 5 (8):
Problem 6 (12):
Problem 7 (12):
Problem 8 (18):
Extra Credit (4):
Total (100):
PROBLEM 1: Development of technology (5 points total)
Eureka! You have just created what could be an HIV vaccine. Describe the steps which you must undertake before you can obtain FDA approval to market this vaccine.
Pre clinical testing in animals
Phase I testing in healthy volunteers to monitor safety
Phase II testing to monitor safety and efficacy
Phase III testing to monitor safety and efficacy
FDA submission for approval to market
PROBLEM 2: Multiple choice. 3 pts each (18 points total).
a. Bordetella pertussis and Influenza A virus are examples of respiratory pathogens; bacterial and viral, respectively. As such, they can both:
Reproduce extracellularly, in saliva and lung fluids
Be killed with antibiotics
Reproduce inside lung cells
Cause inflammation and coughing
Answer:d (viruses can’t reproduce outside cells, or be killed with antibiotics, bordatella can’t reproduce inside lung cells, so the only common thing between them is causing inflammation)
b. If a pathogen penetrates the skin barrier, which of the following action (s) will your immune system take as a first step to fight infection:
Activate B-cells to generate antibodies against it
Activate T-cell responses to kill infected cells
Launch macrophages and inflammatory molecules to signal infection
Release platelets to drive coagulation and prevent the pathogen from entering the blood flow
Answer: c (innate imunity-macrophages and inflammation-