Floating Kollidon SR (KSR) Matrix Tablets Containing Famotidine
Floating Kollidon SR (KSR) matrix tablets containing famotidine was developed to increase gastric residence time and bioavailability after oral administration. Total six formulations were formulated by direct compression technique using varying concentrations of Kollidon SR (floating agent). The formulations were evaluated for their drug content, hardness, friability, buoyancy lag time, total floating time, swelling index and invitro drug release. All formulations possessed good floating properties with total floating time >12 hrs.
Introduction & Objectives
Oral administration is the most convenient and preferred means of any drug delivery to the systematic circulation. Oral sustained release drug delivery have recently been of increasing …show more content…
The tablets were dedusted and reweighed. The tablets that loose less than 1% weight were considered to be compliant.4
Weight variation
10 tablets were selected randomly from the lot and weighed individually to check for weight variation.4
Drug Content Estimation
The drug content in each formulation was determined by triturating 20 tablets and powder equivalent to average weight was added in 100 ml of 0.1N hydrochloric acid. The solution was filtered through a 0.45μ membrane filter, diluted suitably and the absorbance of resultant solution was measured spectrophotometricaly at 267 nm using 0.1N hydrochloric acid as blank.5
Determination of Swelling Index4
The swelling index of tablets was determined in 0.1N HCl (pH 1.2) at room temperature. The swollen weight of the tablet was determined at predefined time intervals over a period of 8 h. The swelling index (SI), expressed as a percentage, and was calculated from the following equation, In-vitro buoyancy …show more content…
formulation F3, F4, F5 and F6 were found to have satisfactory in-vitro floatability. In case of F1 and F2, in-vitro floatability was found to be less than satisfactory, mainly due to the comparatively low concentration of Kollidon SR. Drug release form F1 and F2 was comparatively faster than F3, F4, F5 and F6. It was found that the drug release got slower with increase in the concentration of Kollidon SR. We can conclude that the floating matrix tablets of famotidine can be developed that can effectively sustain the drug release for a desired period. Among the formulations examined, F3 was found to be the best sustained release floating formulation for 12 h. Further, potential of the floating matrix tablet of famotidine with Kollidon SR to improve its bioavailability in humans need to be
Introduction & Objectives
Oral administration is the most convenient and preferred means of any drug delivery to the systematic circulation. Oral sustained release drug delivery have recently been of increasing …show more content…
The tablets were dedusted and reweighed. The tablets that loose less than 1% weight were considered to be compliant.4
Weight variation
10 tablets were selected randomly from the lot and weighed individually to check for weight variation.4
Drug Content Estimation
The drug content in each formulation was determined by triturating 20 tablets and powder equivalent to average weight was added in 100 ml of 0.1N hydrochloric acid. The solution was filtered through a 0.45μ membrane filter, diluted suitably and the absorbance of resultant solution was measured spectrophotometricaly at 267 nm using 0.1N hydrochloric acid as blank.5
Determination of Swelling Index4
The swelling index of tablets was determined in 0.1N HCl (pH 1.2) at room temperature. The swollen weight of the tablet was determined at predefined time intervals over a period of 8 h. The swelling index (SI), expressed as a percentage, and was calculated from the following equation, In-vitro buoyancy …show more content…
formulation F3, F4, F5 and F6 were found to have satisfactory in-vitro floatability. In case of F1 and F2, in-vitro floatability was found to be less than satisfactory, mainly due to the comparatively low concentration of Kollidon SR. Drug release form F1 and F2 was comparatively faster than F3, F4, F5 and F6. It was found that the drug release got slower with increase in the concentration of Kollidon SR. We can conclude that the floating matrix tablets of famotidine can be developed that can effectively sustain the drug release for a desired period. Among the formulations examined, F3 was found to be the best sustained release floating formulation for 12 h. Further, potential of the floating matrix tablet of famotidine with Kollidon SR to improve its bioavailability in humans need to be