Gene Knockdown Essay
The process of genetic modification of existing genes in mammals by RNA interference is called Gene Knockdown. Gene Knockdown occurs by Messenger RNA (mRNA) being targeted so that it can no longer carry out its normal function. This happens by double stranded RNA (dsRNA) being introduced to the selected cell. The dsRNA then begins producing small interfering RNA (siRNA) which bind to the mRNA product of the target gene, and make it inactive. Double stranded RNA makes the targeted gene inactive by binding to an Argonaute protein. The RNA strand and Argonaute combination are a component of the group called RISC – RNA Induced Silencing Complex. The siRNA then directs RISC to the targeted messenger RNA base pairing and the two are bound to each
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This would happen by the same process as the targeting of the LGB protein, except the base coding for the targeted gene would be different as it would depend on which protein was being targeted. This would be effective in reducing things such as allergies or allergic reactions, because allergies can often be hereditary but not guaranteed that the offspring will suffer from the allergy. If the coding of the hereditary allergy tendency were to be targeted it could save the lives of many organisms who suffer from severe life threatening allergies. The targeting of the hereditary gene would be effective in reducing number of deaths from allergies as the organism would no longer have coding to be allergic to things such as peanuts, pollen (hayfever), dust mites and pet allergens. This is an impact on both the health and survival of individuals and survivals of populations, as individuals would be able to live a life that would no longer be affected by their certain allergy, and the population would grow as less people would be affected by their severe allergies and therefore living longer.
Another biological implication of gene knockdown is that it doesn’t stop the gene from being inherited in the cow’s genetic make-up, but prevents it from being active. This means that the gene count of the cow stays at the normal number
This would happen by the same process as the targeting of the LGB protein, except the base coding for the targeted gene would be different as it would depend on which protein was being targeted. This would be effective in reducing things such as allergies or allergic reactions, because allergies can often be hereditary but not guaranteed that the offspring will suffer from the allergy. If the coding of the hereditary allergy tendency were to be targeted it could save the lives of many organisms who suffer from severe life threatening allergies. The targeting of the hereditary gene would be effective in reducing number of deaths from allergies as the organism would no longer have coding to be allergic to things such as peanuts, pollen (hayfever), dust mites and pet allergens. This is an impact on both the health and survival of individuals and survivals of populations, as individuals would be able to live a life that would no longer be affected by their certain allergy, and the population would grow as less people would be affected by their severe allergies and therefore living longer.
Another biological implication of gene knockdown is that it doesn’t stop the gene from being inherited in the cow’s genetic make-up, but prevents it from being active. This means that the gene count of the cow stays at the normal number