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gluten
A&P 2

Gluten Sensitivity Prevalence and Validity

Gluten sensitivity is clearly recognized in the context of celiac disease and wheat allergy. Recently however, a prevalence of complaints of symptoms (inflammation, joint pain, bloating, fogginess, etc..) in response to ingesting "gluten," raises new questions in the research and validity of Non-Celiac Gluten Sensitivity (NCGS.) For years, I have personally dealt with pain, inflammation and bloating. It was not until a whole battery of tests, ranging from visits to various specialists and repeated blood test, that I finally went the alternative route and visited Northampton Wellness Associates in Northampton, where more extensive testing is available.

My NP couldn’t explain the anemia on my blood charts. She had ruled out an iron, B-12 deficiency and various other causes of Anemia. I began to suspect that the Headaches, Depression, bloating, Arthritic pain and swelling of the joints may be caused by inflammation (an autoimmune response.) The Drs. at Northampton Wellness suggested testing for gluten sensitivity. (A test not administered by my primary care team.) And indeed a gluten sensitivity showed up. In order to rule out Celiac disease I would have to undergo a biopsy of my intestines. Needless to say, I said “no thanks” to that.

Now came the real challenge: Going gluten free and observing the results. What transpired was nothing short of astonishing!
The headaches disappeared almost completely and the joint pain and inflammation is reduced by over 80%. Wow, I thought, all my life I have dealt with some of these issues and they only seemed to be getting worse. And here they are nearly all gone with one simple change.
Relief is a gross understatement in describing how I now feel. Relieved and grateful.

This leads me to question how valid this diet is for the general population. Is Gluten



References: Anonymous. Therapeutic Guidelines: Gastrointestinal Version 5, 2011, Therapeutic Guidelines Limited: Melbourne, Australia. Anderson RP et al. In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nat Med. 2000;6(3):337–42. Haines ML, Anderson RP, Gibson PR. Systematic review: the evi- dence base for long-term management of coeliac disease. Aliment Pharmacol Ther. 2008;28(9):1042–66. • Kupfer SS, Jabri B. Pathophysiology of celiac disease. Gastrointest Endosc Clin N Am. 2012;22:639–60. Up-to-date review on develop- ments in the pathogenesis of celaic disease in terms of genetics, immunology and environment. Kagnoff MF. Two genetic loci control the murine immune response to A-gliadin, a wheat protein that activates coeliac sprue. Nature. 1982;296(5853):158–60. Lundin KE, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, et al. Gliadin-specific, HLA-DQ(alpha 1*0501, beta 1*0201) restrict- ed T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med. 1993;178(1):187–96. Lundin KE, Gjertsen HA, Scott H, Sollid LM, Thorsby E. T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8. Hum Immunol. 1994;41(4):285–91. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol. 2002;2(9):647–55. Catassi C, Kryszak D, Bhatti B, Sturgeon C, Helzlsouer K, Clipp SL, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010;42(7):530–8. Holtmeier W, Caspary WF. Celiac disease. Orphanet J Rare Dis. 2006;1:3. •• Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, et al. The Oslo definitions for coeliac disease and related terms. Gut. 2013;62(1):43–52. Important international effort to define various

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