Herbal Remedies Case Study

1.2.Treatment based on herbal remedies:-
Herbal treatment designed to control infection and improve symptoms, correct imbalance and adjust immune system, prevent and treat later disease and/or complication, prevent relapse, and most importantly, to boost energy and strong body for better health and quality of life.The purpose of herbal treatment is not to take the place of necessary orthodox medical treatment. Combination of the both is a better choice.(8)
HERBS OF CHOICE Due to the main reasons listed below we recommend TTB herbal combination typically selecting from the following. And other herbs if necessary, according to symptoms. All these herbs proved to be effective.
• Garlic
• Echinacea (Echinacea
Prolonged gastric retention improves bioavailability, reduces drug waste, and improves solubility for drugs that are less soluble in a high pH environment. Gastro retentive systems (GRDDS) are designed on the basis of delayed gastric emptying and CR principles, and are intended to restrain and localize the drug delivery device in the stomach or within the upper parts of the small intestine until all the drug is releasedConventional oral dosage forms such as tablets, capsules provide specific drug concentration in systemic circulation without offering any control over drug delivery and also cause great fluctuations in plasma drug levels. Although single unit floating dosage forms have been extensively studied, these single unit dosage forms have the disadvantage of a release all or nothing emptying process while the multiple unit particulate system pass through the GIT to avoid the vagaries of gastric emptying and thus release the drug more uniformly. The uniform distribution of these multiple unit dosage forms along the Gastrointestinal Tract (GIT) could result in more reproducible drug absorption and reduced risk of local irritation; this gave birth to oral controlled drug delivery and led to development of Gastro-retentive floating bioadhesive tablet.
2) Drugs that are primarily absorbed in the stomach;
3) Drugs that are poorly soluble at an alkaline pH; (Drugs insoluble in intestinal fluids(acid soluble basic drugs):- chlordiazepoxide, chlorpheniramine, cinnarizine, diazepam, diltiazem, metoprolol, propranolol, quinidine, salbutamol, and verapamil.
4) Drugs absorbed rapidly from GI tract. 5) Drugs that degrades in floating and unstable in lower part of GI tract: captopril.
6) Drugs exhibiting site-specific absorption in the stomach or upper parts of the small intestine
7) Drugs with variable bioavailability: sotalol hydrochloride and levodopa.(12)
1.3.2 Gastroretentive Technologies:-
A number of systems have been pursued to increase the gastric residence time of dosage forms by employing a variety of concepts. These systems have been classified according to the basic principles of gastric retention .
1.Floating Drug Delivery System, with low density providing sufficient buoyancy to float over the gastric contents. 2. Bioadhesive systems, enabling the localized retention of the system in the stomach. 3. Swelling and expanding systems, preventing transit from the gastric