How Do Transition Metals Affect The P53 Protein

There are a number of ways in which transition metals affect the p53 protein and its activity. Some transition metals can be potent inducers of ROS through e.g. the Fenton reaction in which
There are a number of ways in which transition metals affect the p53 protein and its activity. Some transition metals can be potent inducers of ROS through e.g. the Fenton reaction in which superoxide anions and hydrogen peroxide are converted into hydroxyl radicals or through Fenton-like reactions generating a variety of other anions 43. The hydroxyl radicals are particularly prone to cause DNA damage. Notably, some metals are known to cause epigenetic changes such as methylation and could therefore regulate p53 transcription and protein expression. In