Significant advances in medicine have made it easier and safer to transplant organs. While it used to be that organ recipients often needed to be related to their donors in order to reduce the chance of rejection, new innovations in anti-rejection drugs have made it so people can safely receive organs from strangers. As a result, efforts to recruit organ donors have increased considerably over the years. While as of 2011 it is legal in some countries, such as Iran, to sell an organ, many countries have made it illegal to do so. The restriction on selling organs may apply to organs harvested from both living and dead donors. As a result, patients in need of an organ transplant have to rely on organs harvested from those who are dead or from volunteers who are willing to undergo major surgery and the loss of vital organ without any form of compensation.
The desperation of some patients and their families means that they may be willing to pay a significant amount of money for a healthy organ. Some individuals network to try and match potential donors with patients who are in need of organ donation. These individuals may operate in developing countries where equally desperate people are willing to sell their organs with little consideration of the effect that the operation may have on their health and where any monetary