Hyperthermia Case Study Essay

Title: Case study

Jose R Tapanes

International Institute for health Care Professionals

Case 1

Answers

1- malignant hyperthermia is a medical condition with a genetic pattern, due to a subclnical myopathy causing severe reaction to a dose of anesthetics. It is associated with mutations in two genes: RYR1, which encodes the skeletal muscle isoform of the calcium-release channel of the sarcoplasmic reticulum (ryanodine receptor type 1 [RYR-1]), and CACNA1S, which encodes the alpha subunit of the L-type calcium channel isoform of the sarcolemma. An aberrant termination of RYR-1 activity is found in susceptible persons
Early signs include an increase in end-tidal carbon dioxide, tachycardia, muscle rigidity, tachypnea, hyperkalemia, dysrhythmias, and a sympathetic catecholamine. The
The first and most important step is to immediately stop giving the triggering medication and to stop the surgery.
Additional treatment can include:
• Lowering body temperature with:
Cool mist and fans
Cooling blankets
Cooled intravenous fluids

• Administering oxygen
• Using medications to:
Control the heartbeat
Stabilize blood pressure
• Monitoring in an intensive care unit Medication: Dantrolene 1 mg/kg continuous rapid intravenous push and continued until symptoms subside or the maximum cumulative dose of 10 mg/kg has been reached. As soon as the malignant hyperthermia reaction is recognized, all anesthetic agents should be discontinued.

Case 2