Clinical Biochemistry
Dec-2016
Diabetes Mellitus is a heterogeneous disorder, in which IDDM, and NIDDM are the major types. Insulin-dependent diabetes mellitus (IDDM, type 1) is frequently arisen when the immune system recognizes β-cells of pancreatic islet and destroys them. As a result, the body is not able to metabolize glucose properly due to lack of insulin production. It is usually affected young adults who are less than forty years old, and characterized by polyuria, polydipsia, polyphagia, weight loss, nausea and vomiting. On the other hand, non insulin-dependent diabetes mellitus (NIDDM, type 2) is developed when body is not able to utilize insulin correctly. This insulin resistance might be a result of lifestyle, genetic