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Investment Banking
GOOD SAMARITAN COLLEGES-COLLEGE OF ALLIED HEALTH PROFESSIONS
____________________________________________________________________________________

Effectivity of Guyabano (Annona muricata Linn) Leaf Extract in Hyperglycemic Induced Experimental Albino Mice (Mus musculus)

An undergraduate thesis
Presented to
The Faculty of the
College of Allied Health Professions
Good Samaritan Colleges
Cabanatuan City
________________________________________________

In partial fulfillment of the requirements in Introduction to Laboratory Research for the
Degree of Bachelor in Medical Laboratory Science
_________________________________________________________________________

INVESTIGATORS:

Joyce Anne G. Ruiz
Kris B. Guevarra
Marianne Louise R. Ferrer
BMLS 3

PRESENTED TO:
Dr. Joselito D.G. Dar

2013
Chapter 1
Introduction

background of the study Three hundred sixty six (366) million people worldwide suffered from Diabetes Mellitus (DM) last 2011 and will rapidly increase through the following years. 4.6 million of them died and 183 million people (50%) remain undiagnosed. Even children (78,000) are affected by this disease (International Diabetes Federation, 2011). These rates show that DM is an alarming and fatal disease throughout the world and the fact that it does not choose whatever age, gender, race or type of people there are is terrifying.
Diabetes Mellitus is a metabolic disease that is characterized by an increase in normal plasma glucose level resulting from imbalance of hormones, insulin secretion defects, insulin action or all. It is the 9th out of 86 major cause of death in the whole world ( World Life Expectancy, 2010) and 6th to the Philippines causing 18, 512 deaths in the country ( World Health Rankings, 2010). There are two categories of DM: type 1 (Insulin-dependent diabetes mellitus) and type 2 (non-insulin-dependent diabetes mellitus). Type 1 diabetes is characterized by hyperglycemia due to the destruction of
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