Lectin Pathway
Complement is a system consisting of multiple proteins, available in plasma under the inactive form, mainly produced by the liver. Complement plays an important role in infection control.
Involve in lysis activity, opsonic activity, join inflammation and fight infection
Activation of the classical pathway needs the participation of the complement C1, C4, C2. Activation of the complement classical pathway usually begins with the formation of complex antigen-antibody dissolved either by binding of antibodies to the antigens on an appropriate destination such as a cell bacteria. IgM and IgG subclass (IgG1, IgG2 and IgG3) can activate the classical pathway. The first phase of the activation process involves a continuous chain enzymes C1, C4, C2 …show more content…
This pathway involves 4-serum protein that is C3, factor B, factor D and properdin. Unlike classical pathway is first required to activate antibody in most cases, Alternate pathway was first activated by the composition of different cell surface components. For example, both gram-negative and gram-positive bacteria are the components of the cell wall cannot activate the classical path.
This path is triggered via the protein that binds to carbohydrates. Lectin path started when serum protein called mannose-binding lectin (MBL) binds to mannose is the original composition of the glycoprotein or carbohydrate molecules on the surface of the microorganism. Lectin binds to mannose original road surface bacteria. Activation of the lectin molecule activates 2 MASP-1, when MASP-1 is activated 2 molecule activates MASPP-2, and MASP-2 is activated, C2 and C4. From here the activation like the classical pathway.
Classical pathway is triggered when the C1 complex attached to the antigen-antibody. The alternate active when C3B bind to activated surfaces such as a bacterial cell. The lectin started when lectin attached mannose (MBL) foreign objects attached to the
Involve in lysis activity, opsonic activity, join inflammation and fight infection
Activation of the classical pathway needs the participation of the complement C1, C4, C2. Activation of the complement classical pathway usually begins with the formation of complex antigen-antibody dissolved either by binding of antibodies to the antigens on an appropriate destination such as a cell bacteria. IgM and IgG subclass (IgG1, IgG2 and IgG3) can activate the classical pathway. The first phase of the activation process involves a continuous chain enzymes C1, C4, C2 …show more content…
This pathway involves 4-serum protein that is C3, factor B, factor D and properdin. Unlike classical pathway is first required to activate antibody in most cases, Alternate pathway was first activated by the composition of different cell surface components. For example, both gram-negative and gram-positive bacteria are the components of the cell wall cannot activate the classical path.
This path is triggered via the protein that binds to carbohydrates. Lectin path started when serum protein called mannose-binding lectin (MBL) binds to mannose is the original composition of the glycoprotein or carbohydrate molecules on the surface of the microorganism. Lectin binds to mannose original road surface bacteria. Activation of the lectin molecule activates 2 MASP-1, when MASP-1 is activated 2 molecule activates MASPP-2, and MASP-2 is activated, C2 and C4. From here the activation like the classical pathway.
Classical pathway is triggered when the C1 complex attached to the antigen-antibody. The alternate active when C3B bind to activated surfaces such as a bacterial cell. The lectin started when lectin attached mannose (MBL) foreign objects attached to the