Lidocaine Hydrochloride Case Study
Introduction:
Lidocaine hydrochloride a local anaesthetic drug is widely used in skin anaesthesia. Rapid achievement of dermal anaesthesia without discomfort and pain is both disusable and difficult. Also the topical delivery of the drugs reaches the systemic circulation only in sub-therapeutic concentrations due to poor permeation and immiscible nature of the drug at skin pH. These limitations can by overcome by iontophoresis technique.
Objective:
The aim of the present study is to develop the invitro study model of iontophoretic drug delivery system of Lidocaine hydrochloride to increase the permeation of the drug across the skin by using Different current intensities(0.05mA,
0.25mA, & 0.5mA) with different concentrations(5% V/V, 10% V/V, 20% …show more content…
The fold increase was found to be upto two folds
Among the permeation enhancers (SLS, PEG 400, and DMSO), SLS showed higher release than DMSO and PEG 400. It may be due to its charged form. Also increase in concentration of enhancers lead to increase in the cumulative % release
Hence the current density could be reduced to an optimum level when used in combination with the enhancers. The release produced by a higher current density could be effectively produced at lower current densities in the presence of chemical enhancers By using an optimum quantity of current and chemical enhancer, patient safety can be ensured and the Iontophoresis technology could be subjected to long term use and its potential benefits could be utilized by the patients in the management of pain
Hence the ultimate aim of developing the iontophoretic drug delivery system of
Lidocaine hydrochloride in combination with chemical permeation enhancers
Lidocaine hydrochloride a local anaesthetic drug is widely used in skin anaesthesia. Rapid achievement of dermal anaesthesia without discomfort and pain is both disusable and difficult. Also the topical delivery of the drugs reaches the systemic circulation only in sub-therapeutic concentrations due to poor permeation and immiscible nature of the drug at skin pH. These limitations can by overcome by iontophoresis technique.
Objective:
The aim of the present study is to develop the invitro study model of iontophoretic drug delivery system of Lidocaine hydrochloride to increase the permeation of the drug across the skin by using Different current intensities(0.05mA,
0.25mA, & 0.5mA) with different concentrations(5% V/V, 10% V/V, 20% …show more content…
The fold increase was found to be upto two folds
Among the permeation enhancers (SLS, PEG 400, and DMSO), SLS showed higher release than DMSO and PEG 400. It may be due to its charged form. Also increase in concentration of enhancers lead to increase in the cumulative % release
Hence the current density could be reduced to an optimum level when used in combination with the enhancers. The release produced by a higher current density could be effectively produced at lower current densities in the presence of chemical enhancers By using an optimum quantity of current and chemical enhancer, patient safety can be ensured and the Iontophoresis technology could be subjected to long term use and its potential benefits could be utilized by the patients in the management of pain
Hence the ultimate aim of developing the iontophoretic drug delivery system of
Lidocaine hydrochloride in combination with chemical permeation enhancers