According to Jerome Groopman in “Marijuana: The High and the Low” states that studies on the medical uses for marijuana may contradict the views on legalizing the substance due to the pros and cons of how the chemical may react to a human being. The author shows how the biological effects of cannabinoids, the active chemical compounds in the marijuana plant can be used in medical uses. The work from the scientist, Professor Raphael Mechoulam proved how this chemical can be used in a positive aspect. He discovered the first endogenous cannabinoid, a fatty acid in the brain which he termed “anandamide.” When this is attached to CB1, it triggers a biochemical change within our neurons. The receptor site of CB1 binds to THC, the primary psychoactive