Mechanism of Melatonin Stimulation of Growth Hormone Release Via Somatostatin Inhibition
Mechanism of melatonin stimulation of growth hormone release via somatostatin inhibition
Joseph Angelo Israel Peguit
University of the Philippines in the Visayas Cebu College
Natural Sciences and Mathematics Division
Abstract
Secretion of growth hormone is affected by two primary hormones: Growth hormone-releasing hormone and somatostatin. The former is the primary stimulant to promote growth hormone secretion while the latter is the primary inhibitor that prevents growth hormone secretion. Many studies have already shown that melatonin stimulates secretion of growth hormone via somatostatin inhibition but its mechanisms remain unknown. I hypothesized that melatonin inhibits somatostatin at transcription level through inhibition of important somatostatin transcription factors. I collected data from primary and secondary literature to acquire information on the target tissues, receptors and cellular mechanisms of melatonin. I collected information about somatostatin with emphasis on the mechanisms of its expression. Results showed that melatonin inhibits transcription of somatostatin through inhibition of Cyclic-adenosine monophosphate response element binding protein (CREB) which is a constituent of the transcription factors for somatostatin expression.
I. Introduction
Melatonin is a major secretion of the pineal hormone primarily involved in animal sleeping patterns. For such function, people have been taking melatonin pills over the counter to cure sleeping disorders. Approval from FDA on these melatonin pills is not yet available since the total function of this hormone has not been fully known. However, intensive researches have been going on trying to elucidate the entire function of this hormone. Full understanding on the physiology of this hormone may precede medical innovations as it can help us understand more of our development. One of the recent discoveries on this hormone is its ability to act as an antioxidant at the same time
Joseph Angelo Israel Peguit
University of the Philippines in the Visayas Cebu College
Natural Sciences and Mathematics Division
Abstract
Secretion of growth hormone is affected by two primary hormones: Growth hormone-releasing hormone and somatostatin. The former is the primary stimulant to promote growth hormone secretion while the latter is the primary inhibitor that prevents growth hormone secretion. Many studies have already shown that melatonin stimulates secretion of growth hormone via somatostatin inhibition but its mechanisms remain unknown. I hypothesized that melatonin inhibits somatostatin at transcription level through inhibition of important somatostatin transcription factors. I collected data from primary and secondary literature to acquire information on the target tissues, receptors and cellular mechanisms of melatonin. I collected information about somatostatin with emphasis on the mechanisms of its expression. Results showed that melatonin inhibits transcription of somatostatin through inhibition of Cyclic-adenosine monophosphate response element binding protein (CREB) which is a constituent of the transcription factors for somatostatin expression.
I. Introduction
Melatonin is a major secretion of the pineal hormone primarily involved in animal sleeping patterns. For such function, people have been taking melatonin pills over the counter to cure sleeping disorders. Approval from FDA on these melatonin pills is not yet available since the total function of this hormone has not been fully known. However, intensive researches have been going on trying to elucidate the entire function of this hormone. Full understanding on the physiology of this hormone may precede medical innovations as it can help us understand more of our development. One of the recent discoveries on this hormone is its ability to act as an antioxidant at the same time
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