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Medical Immunology

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Medical Immunology
MEDICAL IMMUNOLOGY & SEROLOGY

Terence L. Eday, RMT, MT(ASCPi), MPH
College of Medical Technology / Medical Laboratory Science

University of Perpetual Help System DALTA

Historical Perspective
• 1773, Voltaire reported on an ancient Chinese custom where dried and powdered small pox scabs were inhaled
• 1798, Edward Anthony Jenner, Smallpox vaccination • 1862, Ernst Haekel, Recognition of phagocytosis

• 1877, Paul Erlich, recognition of mast cells

Historical Perspective
• 1879, Louis Pasteur, Attennuated chicken cholera vaccine development • 1883, Ellie Metchnikoff developed the cellular theory of immunity through phagocytosis; phagocytic theory; cellular theory of vaccination
• 1885, Pasteur discovered therapeutic vaccination; first report of live “attenuated” vaccine for rabies

Historical Perspective
• 1888, Pierre Roux & Alexander Yersin, Bacterial toxins (Yersinia pestis) • 1888, George Nuttall, Bactericidal action of blood
• 1890, Emil von Behring and Kitasata introduced passive immunization into modern medicine; humoral theory of immunity • 1891, Robert Koch demonstrated the cutaneous (delayed-type) hypersensitivity • 1894, Richard Pfeiffer, Bacteriolysis

Historical Perspective (1 of 6 )
• 1895, Jules Bordet, Complement and antibody activity in bacteriolysis • 1900, Paul Ehrlich, responsible for the antibody formation theory
• 1901, Karl Landsteiner, A, B, and O • 1901-8, Carl Jensen & Leo Loeb, Transplantable tumors • 1902, Paul Portier & Charles Richet, Anaphylaxis

Historical Perspective (1 of 6 )
• 1903, Nicolas Maurice Arthus, discovered the Arthus reaction of intermediate hypersensitivity
• 1903, Almroth Wright and Stewart Douglas observed the humoral component, opsonin • 1906, Clemens von Pirquet, coined the word allergy • 1907, Svante Arrhenius, coined the term immunochemistry

Historical Perspective
• 1910, Emil von Dungern, & Ludwik Hirszfeld, Inheritance of ABO blood groups
• 1910, Peyton Rous, Viral
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