Abstract
Melamine and other compounds of its kind have been known for several years for toxic and harmful effects. It is certainly true that the degree of effect is proportional to the level of exposure but both humans and animals have suffered because of these compounds. Melamine tableware, including plates, bowls and cups etc., are used in daily life due to their durability and ease of use, especially in case of children. However, a recent epidemic of melamine poisoning in China brought up the issue of melamine toxicity due to tainted milk powder formula and it became clear that food contact materials having melamine are not as safe as they were once thought of. The migration rate of melamine …show more content…
Cancer formed solely in the bladder of animals that developed stones, signifying that the tumors grew as a result of epithelial irritation in the bladder and hyperplasia, not because of a genotoxicity of the chemical.
The use of melamine is associated with the formation of urinary stones in the bladders of children. Furthermore there is speculation that melamine may also be a cause of urolithiasis in adults. To form further firm thought on it, 211 patients and 211 control group people from Taiwan were studied. These patients had calcium urolithiasis. All patients were required to submit urine sampled alongside in depth questionnaires.
It was deduced that the risk increased with increased levels of melamine after adjusting for externalities such as tobacco smoking, betel quid chewing, alcohol use etc. Those with levels of 3.11ng/ml had the risk increase 3.01 fold and those with levels of 3.12ng/ml had the risk increase 7.64 fold. The risk of calcium urolithiasis within the general population was averaged out to be 50% if melamine was found in urine. Additionally, using mass spectrometry it was found that melamine is present in the stone of nine of the patients who had a considerable amount of melamine in their urine. What can be deduced from this is that even a low dose of melamine exposure was a cause of calcium urolithiasis in the adults of