Preview

Merck Decision Tree

Good Essays
Open Document
Open Document
456 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Merck Decision Tree
Merck is a global research-driven pharmaceutical company dedicated to putting patients first. Merck's highest priority areas are Alzheimer’s disease, atherosclerosis, cardiovascular disease, diabetes, novel vaccines, obesity, oncology, pain and sleep disorders. In addition, and importantly for licensing, the following other areas remain of high interest for focused investment in new compounds and mechanisms: antibiotics, antifungals, antivirals (HCV and HIV), asthma, COPD, neurodegeneration, ophthalmology, osteoporosis, schizophrenia, and stroke.

In RNA Therapeutics they are interested in:

siRNA sequence, structure, and modification
Novel chemistries for improving resistance to enzymatic degradation
Novel chemistries for reducing immunostimulation
Enhanced RISC incorporations
Long-term chemical stability
Improved target specificity siRNA delivery vehicles for systemic administration
Novel polymers and lipids for encapsulation
Low toxicity and biodegradable
Amenable to use of process development and manufacturing platforms
Amenable to molecular targeting strategies
Long-term storage stability
Delivery vehicles that improve endosomal escape
Approaches to molecular targeting of siRNA
Targeting using antibodies, peptides, or small molecules
Specific for disease-relevant cell types
Suitable for nanoparticle or liposome delivery
Assays for siRNA intracellular functions
Assays for siRNA endosomal escape
Biochemical assays for strand selection, RISC incorporation, and catalytic efficiency
Assays for clinical biodistribution
Cell-based assays to measure toll receptor activation
Validated siRNA targets
Demonstrated reduction in mRNA and protein levels in animals
Reductions have expected effect on disease phenotype miRNA Novel chemistries to create antagomirs
Demonstrated reduction of miRNA levels in animals, with evidence that reductions have expected effects on mRNA levels and/or disease phenotype
Demonstrated

You May Also Find These Documents Helpful

  • Satisfactory Essays

    Scm421merckcasereport 2

    • 790 Words
    • 3 Pages

    The Opportunity: Merck, a global, research-driven pharmaceutical company, has core values invested in cutting edge science programs. Recently the organization was accosted by Kappa Labs with a proposal to purchase the product KL-798. This drug is associated with obesity and weight-loss which is becoming a valuable investment to the pharmaceutical industry.…

    • 790 Words
    • 3 Pages
    Satisfactory Essays
  • Good Essays

    1. Why does Merck want to switch Pepcid to OTC status when the patent is good for another six years? How attractive is this opportunity?…

    • 619 Words
    • 3 Pages
    Good Essays
  • Satisfactory Essays

    Fi561 You Decide

    • 430 Words
    • 2 Pages

    I’m concerned about synergy and integration issues between our highly research-oriented development of pharmaceuticals here at Merck, and a prescription medicine marketing company like Medco. I am concerned that the cultures and operations of the two companies aren’t going to mix well, and that this deal would result in an expensive failure.…

    • 430 Words
    • 2 Pages
    Satisfactory Essays
  • Good Essays

    The actions Merck undertook when marketing Vioxx and emphasizing its safety even after finding out the product’s side effects endangered all its key stakeholders and showed the real face of the company that accented its highly ethical maxims. Cardiovascular side effects of the Vioxx increased the risk of complications that could have caused patient’s death, therefore Merck violated the basic right to life of all the Vioxx consumers. It was already mentioned that Vioxx caused 3468 deaths by heart attack and stroke. All these tragedy events could have been prevented if Merck provided adequate information about all the peculiarities of Vioxx. Even though Merck argued that the withdrawal of tests results was caused by its utilitarian intention…

    • 578 Words
    • 3 Pages
    Good Essays
  • Better Essays

    Chem Lab

    • 858 Words
    • 4 Pages

    (2) The Merck Index: An Encyclopedia of Chemicals and Drugs, 12th edition. Siegmund, O.H.; Merck and Co: NJ,137,220.…

    • 858 Words
    • 4 Pages
    Better Essays
  • Powerful Essays

    Merck is a well-run company with advanced in-house R&D capabilities. Although the company is not completely admonished from faltering performances by its competitors, many believe this offsets any setbacks from strong sales of new product approvals like Victrelis as well as cost- cutting efforts.…

    • 1517 Words
    • 7 Pages
    Powerful Essays
  • Powerful Essays

    Merck & Co. Inc. is one of the world’s largest pharmaceutical companies in the world for producers of prescription drugs. Merck had sales of 1.98 billion and net income of 307 million in 1978 and continues to steadily rise. Merck invested hundreds of millions of dollars each year in research and allocate the funds amongst various projects. On average it would take approximately 12 years and 200 million dollars to bring a new drug into the market. Many potential drugs offered little chance of financial returns, as some diseases were so rare that treatment could never be priced high enough for the company to recoup the investment. Congress sought to encourage drug companies to further research on rare diseases by proposing tax benefits and seven-year exclusive marketing rights if they manufactured drugs for diseases afflicting fewer than 200,000 Americans. River blindness, also known as “onchocerciasis” is a disease found in over 35 developing countries throughout the Third World. The cause of the disease came from parasitic worm that were carried by black flies. In 1978, the World Health Organization (WHO) estimated that approximately 340,000 people were blind because of this disease and 18 million or more were infected with the parasite, but not many showed symptoms. Merck researchers have found a compound called ‘Ivermectin’, which has proven to have an astonishing effect against wide range of parasites in animals. Dr. Campbell proposed the idea to have the compound formulated to work against human parasite, but the success rate was very low. Even if the drug was successful attained, the economy viability would be nil and no U.S. or international program would create any incentives for Merck to develop drugs for diseases like river blindness.…

    • 829 Words
    • 3 Pages
    Powerful Essays
  • Better Essays

    The RNAi mechanism is found in many different eukaryotes and it is started by an enzyme names Dicer. Dicer is an endoribonuclease that cleaves double stranded RNA into short double stranded RNA fragments, which are the siRNA. Each of these new siRNAs are then unwound into two different single stranded ssRNAs. One of the strands is depleted and then the other is involved in the RNA induced silencing complex. RNAi is a very valuable in research. This is because double stranded RNAs that are introduced into the cell can induce suppression of some specific genes of interest. Andrew Fire and Craig C. Mello’s work on RNAi in C. Elegans revolutionized RNAi, and because of it the usefulness of it has increased substantially. RNAi can be easily introduced into the C. Elegans through feeding; feeding the worms the bacteria that expresses double stranded RNA that corresponds to the gene that is being targeted can do this.…

    • 2580 Words
    • 11 Pages
    Better Essays
  • Good Essays

    Merck's Culture

    • 435 Words
    • 2 Pages

    “May 5, 2005. It was the darkest hour in the pharmaceutical giant 's 114-year history. Merck was drowning in liability suits stemming from Vioxx, its $2.5 billion-a-year arthritis drug, which it had to pull from the market because of a link to heart attacks and strokes. Two other blockbusters worth a combined $7 billion in annual sales were facing patent expirations. And Merck 's labs, which other companies once hailed as a bastion of scientific innovation, were crippled by a culture that buried good ideas under layers of bureaucracy. But in the morass, Clark saw opportunity (www.businessweek.com).”…

    • 435 Words
    • 2 Pages
    Good Essays
  • Good Essays

    Wistar Factor Model

    • 884 Words
    • 4 Pages

    CCK-8 assay and FITC apoptosis detection kit will detect a low to no cellular proliferation and apoptosis. This is due to AFB1 not being present and therefore not contributing to the upregulation of miR-155. In the case of the experimental rats, RT-qPCR will present a large amount of miR-155 expression levels. Moreover, CCK-8 assay and FITC will show an increased rate of cellular proliferation and a decrease in cellular apoptosis respectively. An indication that AFB1 toxin has a connection with miR-155 in causing HCC. If this was the case, the next step in our research would be to determine if miR-155 causes HCC to develop in BA via the activation of Wnt/β-catenin…

    • 884 Words
    • 4 Pages
    Good Essays
  • Better Essays

    Merck & Co

    • 1066 Words
    • 5 Pages

    Merck had a 14% increase in sales between 1997 and 1998 and 22% increase in sales from 1998 – 1999, and a 13% annual increase in earnings over the same period. Merck’s business strategy consists of two parts: (1) developing and marketing new drugs through internal research, and (2) developing partnerships with smaller biotechnology companies. Since 1995, Merck had launched 15 new products that earned $5.9 billion on sales of $32.7 billion. Furthermore, Merck may agree to license new drugs from other firms and with its larger capital and greater assets, can assume the risk of submitting the drug through various regulatory approval phases. If the drug becomes profitable, Merck can earn significant cash flows while paying a royalty to the licensor. However, most important is the option that Merck has in deciding when to abandon or continue on this project (deferability or optionality). If Merck reaches a point when its expected NPV is negative, it can simply abandon the project.…

    • 1066 Words
    • 5 Pages
    Better Essays
  • Powerful Essays

    Abgenix Case Analysis

    • 5724 Words
    • 23 Pages

    The product of a seven-year, $40 rnillion research and development effort, XenoMouse was a unique strain of transgenic rnice capable of producing antibodies potentially useful in the treatment of human disorders including cancer, transplant rejectiory and inflammation. The idea of using rnice to produce antibodies for treating human diseases dated back to the 1970s; but only recently had therapies based on this approach passed the rigorous safety and efficacy tests necessary for regulatory approval. Many industry observers were now predicting an "antibody wave" as genornics research identified thousands more possible disease targets for antibody therapy. And, the ner / generation of technologies for generating antibodies from mice, including XenoMouse, were capable of producing therapies which were believed to be more effective and well tolerated by humans. Major pharmaceutical and biotech companies had licensed access to XenoMouse.…

    • 5724 Words
    • 23 Pages
    Powerful Essays
  • Good Essays

    Merck Case

    • 587 Words
    • 4 Pages

    Merck had a 14% increase in sales between 1997 and 1998 and 22% increase in sales from 1998 – 1999, and a 13% annual increase in earnings over the same period. Merck’s business strategy consists of two parts: (1) developing and marketing new drugs through internal research, and (2) developing partnerships with smaller biotechnology companies. Since 1995, Merck had launched 15 new products that earned $5.9 billion on sales of $32.7 billion. Furthermore, Merck may agree to license new drugs from other firms and with its larger capital and greater assets, can assume the risk of submitting the drug through various regulatory approval phases. If the drug becomes profitable, Merck can earn significant cash flows while paying a royalty to the licensor. However, most important is the option that Merck has in deciding when to abandon or continue on this project (deferability or optionality). If Merck reaches a point when its expected NPV is negative, it can simply abandon the project. As a licensee, Merck can allow smaller biotechnology firms to focus on research and development. These smaller firms often have smaller budgets and are not financially or personnel equipped to handle the costly and long FDA approval process, and the subsequent marketing, distribution, and sales of new drugs. This task is better suited for a larger company, such as Merck, which has more resources and money.…

    • 587 Words
    • 4 Pages
    Good Essays
  • Good Essays

    Biacore SPR Lab Report

    • 1407 Words
    • 6 Pages

    In addition to stabilize the biological function of captured membrane proteins, nanodiscs have some benefits when used together with SPR. Nanodiscs provide access to both sides of the lipid bilayers. Thereby it is possible to avoid problems with orientation and access to integral membrane proteins that can occur when lipid vesicles or supported membrane mono- or bilayers are used to capture membrane proteins on the sensor surface. In addition, the MSP encircling the nanodisc lipidbilayer can increase the flexibility of immobilization strategies; the MSP can be genetically engineered with various affinity tags useful for immobilization on a complementary antibody sensor surface. To date, the MSP has been generated with his- and Flag-tags and recently a C9 epitope…

    • 1407 Words
    • 6 Pages
    Good Essays
  • Powerful Essays

    Algorithym

    • 6418 Words
    • 26 Pages

    we found 1,915 protein-coding genes (8.2%) for which none suitable siRNA sequences can be found.…

    • 6418 Words
    • 26 Pages
    Powerful Essays