Metabolic Syndrome Essay

Metabolic syndrome consists of multiple interrelated risk factors which directly promote the development of atherosclerotic cardiovascular disease (ASCVD).The risk factors include atherogenic dyslipidemia,elevated plasma glucose,elevated blood pressure,proinflammatory and prothromboticstate(1). Prevalence of metabolic syndrome in world population was estimated to be around 20-25%.patients with metabolic syndrome are twice likely to die from Cerebrovascular accident and myocardial infarction.patients with metabolic syndrome are five times more likely to develop type 2 diabetes. Insulin resistence and abdominal obesity are the two significant factors causing metabolic syndrome. A number of commitee had developed clinical criteria for the metabolic syndrome. The most widely used are World Health Organization (WHO), the European Group for the Study of Insulin Resistance (EGIR), and the National Cholesterol Education Program – Third Adult Treatment Panel (NCEP ATP III)(2) Both visceral obesity and insulin resistance are associated with chronic inflammation which is characterized by production of abnormal adipocytokines such as tumor necrosis factor, interleukin-1 (IL-1), IL-6, leptin, and adiponectin(3). Gamma-glutamyl transferase (GGT) plays an important role including oxidative stress and lipid peroxidation, which are important to the pathogenesis and development of insulin resistance and the metabolic syndrome(4). Many studies shown that the level of GGT directly correlates with increased risk of hypertension, diabetes, and metabolic syndrome, even after adjustment for alcohol consumption.(5). GGT is independently associated with cardiovascular mortality. GGT is expressed in several organs and tissues with a central role for intracellular glutathione
This study was conducted to find any association between GGT and metabolic syndrome and

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