Molecular Modelling of the Effects of Penetration Enhancer - Propylene Glycol on Lipid Membrane
Molecular Modelling of the Effects of Penetration Enhancer - Propylene Glycol on Lipid Membrane
By
Rafique Ullah Ethics
UB: 06007693 Under supervision of Dr. Jamshed Anwar
Thesis Submitted in Partial Fulfilment of the Requirements for the Degree of Masters of Science In Pharmaceutical Technology at
The University of Bradford September 2012
Molecular Modelling of the effects of Penetration Enhancer - Propylene Glycol on Lipid Membrane
ABSTRACT Modern medicine has come a long way from its early days, with advanced drugs with higher therapeutic efficiency and minimal toxic effects. However many oral drugs in modern medicine have a rather high hepatic first-pass metabolism, minimizing the drug's effectiveness. Transdermal Delivery of drug molecules into or through the skin can contribute significant improvement over the usual orthodox routes of drug delivery, including circumventing the hepatic metabolism (first-pass), inerratic plasma drug concentration, instant drug action termination capability, better and enhanced control and improved customer/patient compliance. Here investigation was carried out using DPPC bilayer to check the interaction with propylene glycol at different concentrations and subsequent analysis was carried out to understand the mechanism of action. INTRODUCTION Modern medicine has come a long way from its early days, by means of advanced drugs with higher therapeutic efficiency and minimal toxic effects, new delivery methods, etc. However many oral drugs in modern medicine have a rather high hepatic first-pass metabolism, minimizing the drug's effectiveness. Consequently efforts are made continuously to find new methods of drug delivery and improving the existing methods available for by-passing the first pass hepatic metabolism. Transdermal Delivery of drug molecules into or through the skin can contribute significant improvement compared to the usual orthodox routes of drug delivery, including circumventing the hepatic
By
Rafique Ullah Ethics
UB: 06007693 Under supervision of Dr. Jamshed Anwar
Thesis Submitted in Partial Fulfilment of the Requirements for the Degree of Masters of Science In Pharmaceutical Technology at
The University of Bradford September 2012
Molecular Modelling of the effects of Penetration Enhancer - Propylene Glycol on Lipid Membrane
ABSTRACT Modern medicine has come a long way from its early days, with advanced drugs with higher therapeutic efficiency and minimal toxic effects. However many oral drugs in modern medicine have a rather high hepatic first-pass metabolism, minimizing the drug's effectiveness. Transdermal Delivery of drug molecules into or through the skin can contribute significant improvement over the usual orthodox routes of drug delivery, including circumventing the hepatic metabolism (first-pass), inerratic plasma drug concentration, instant drug action termination capability, better and enhanced control and improved customer/patient compliance. Here investigation was carried out using DPPC bilayer to check the interaction with propylene glycol at different concentrations and subsequent analysis was carried out to understand the mechanism of action. INTRODUCTION Modern medicine has come a long way from its early days, by means of advanced drugs with higher therapeutic efficiency and minimal toxic effects, new delivery methods, etc. However many oral drugs in modern medicine have a rather high hepatic first-pass metabolism, minimizing the drug's effectiveness. Consequently efforts are made continuously to find new methods of drug delivery and improving the existing methods available for by-passing the first pass hepatic metabolism. Transdermal Delivery of drug molecules into or through the skin can contribute significant improvement compared to the usual orthodox routes of drug delivery, including circumventing the hepatic