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Mr Michael
A Critical Review of Peters, JW & Williams, LD 2012, ‘The Origin of Life: Look Up and Look Down’, Astrobiology, vol. 12, no. 11, pp. 1087-1092.
The origin of life has always been one of the most attractive features in philosophy and science. Moreover, it can examine our knowledge of biological, geological and chemical principles. This review aims to provide information about consideration of the origin of life. The study reveals that the origin of life can be accomplished in both approaches, from the bottom up or from the top down by a retracing of the transition from prebiotic to biotic. Although the origin of life attracts people to science, it is not easy to define and analyze exactly relationships between planetary evolution, geology and conditions of early earth and biochemistry and biological complexity. John W. Peters and Loren Dean Williams in the article: The Origin of Life: Look Up and Look Down attempt to illustrate the origin of life by some different theories or worlds such as Iron Sulfur World and RNA World and also from very early life on earth to extant life.
Life on earth, seen after approximately 4 billion years of evolution, clearly emerged in an environment with the inherent capacity to produce many of the small molecules required as enzymatic cofactors and for biological polymers (Oparin 1938). With bottom up approach which starts with the conditions and chemicals existing on the early Earth, investigators strive to understand and recapitulate steps in the origin of life, including the formation of precursors, building blocks, polymers, macromolecular assemblies and catalytic functions. In the seminal bottom up experiments of Miller and Urey advanced our understanding of prebiotic chemistry, showing that abiotic process can contribute biomolecule precursors or building blocks. There are a large number of complex organic molecules formed in the experiment, including a number of amino acids. Within weeks after, it presents the discovery of



References: list * Peters, JW & Williams, LD 2012, ‘The Origin of Life: Look Up and Look Down’, Astrobiology, vol. 12, no. 11, pp. 1087-1092. * * Oparin, A.I. (1938) The Origin of Life, MacMillan, New York. Orgel, L.E. (1968) Evolution of the genetic apparatus. J Mol Biol 38:381–393. * * Schmitt-Kopplin, P., Gabelica, Z., Gougeon, R.D., Fekete, A., Kanawati, B., Harir, M., Gebefuegi, I., Eckel, G., and Hertkorn, N. (2010) High molecular diversity of extraterrestrial organic matter in Murchison meteorite revealed 40 years after its fall. Proc Natl Acad Sci USA 107:2763–2768. * .

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