Preview

Myc- Project

Good Essays
Open Document
Open Document
508 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Myc- Project
MYC- is a mutated MYC
MYC participates in the regulation of gene transcription. It binds to DNA in a non-specific manner. MYC controls genetic information flow from DNA to the mrna and plays an important role in controlling cell division. “That role is so powerful that cells co-evolved an emergency death pathway to keep c-Myc expression in check. If c-Myc’s production spins out of control in an otherwise normal cell, the cell immediately commits suicide through a process called apoptosis. But in cancer cells in which c-Myc is overproduced, this suicide pathway is compromised, allowing the cell to survive and proliferate (Young).”
It is a very strong Proto-oncogene that can mutate into an oncogene that can cause cancer and tumors.
MYC- Defects in MYC are a cause of Burkitt lymphoma. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Effect of MYC- alone is unknown but is related to tumor cells.

Chromosomal aberrations involvingmyc family loci have been implicated in the generation of a variety of human tumors and are often strongly correlated to a poor prognosis. Among these are the translocations involving c-mycand the immunoglobulin loci that occur in a high percentage of human Burkitt's lymphoma, AIDS-associated lymphomas, and certain acute lymphoblastic leukemias, resulting in deregulated expression of c-myc
Effect of MYC- alone is unknown but is related to tumor cells.
It turns out that high levels of c-Myc send a tumor cell’s gene expression program into overdrive. Transcription increases dramatically, allowing malignant cells to overwhelm factors that might normally hamper their growth and proliferation. This surprising finding, published in this week’s issue of the journal Cell, provides a simple, elegant explanation for how a single protein can have such profound effect in so many and varied types of cancer. “MYC is a key driver in most major cancers, but it has



Cited: Rura, Nicole. Whitehead Institute: Agreesive cancer exploits MYC oncogene to amplify global gene activity. September 27, 2012 Uniprotkb/Swiss-Prot

You May Also Find These Documents Helpful

  • Good Essays

    Tumor Suppressor genes - They specify proteins that directly and indirectly inhibit the cell cycle…

    • 352 Words
    • 2 Pages
    Good Essays
  • Powerful Essays

    Bortezomib And Irinotecan

    • 1511 Words
    • 7 Pages

    myeloma. It was an exciting observation that bortezomib erased all signs of cancer from a…

    • 1511 Words
    • 7 Pages
    Powerful Essays
  • Good Essays

    Bio 201 Final Review

    • 5203 Words
    • 21 Pages

    - The tumor-suppressor gene and resulting protein may lose its function and ability to suppress cell proliferation.…

    • 5203 Words
    • 21 Pages
    Good Essays
  • Powerful Essays

    Pt1420 Final Exam

    • 3892 Words
    • 16 Pages

    - caused by a MECP2 mutation. This gene is found on a person’s X chromosome…

    • 3892 Words
    • 16 Pages
    Powerful Essays
  • Powerful Essays

    BIO 310 Homework 3

    • 917 Words
    • 4 Pages

    3) What are tumor suppressor genes (11.18-11.19) and what is their role in the cell cycle? Tumor suppressor genes are genes that regulate the growth of cells. When functioning properly, these genes can stop the growth of tumors. They can communicate to the cells when to slow down, when they can divide, and when they can die.…

    • 917 Words
    • 4 Pages
    Powerful Essays
  • Satisfactory Essays

    Nt1310 Unit 1 Assignment

    • 579 Words
    • 3 Pages

    When a cell divides, it's DNA is copied error-free, but sometimes random changes occur called mutations. The changes can result in the death of the cell or allow the cell to live and continue to grow and divide. When the DNA starts to act abnormally, the cells could become cancerous and proliferate wildly through repeated, uncontrolled mitosis and cytokinesis. Some mutations are caused by carcinogens: environmental factors that cause cancer, some include, tobacco smoke, radiation, such as x-rays and UV rays from tanning beds and sunlight.…

    • 579 Words
    • 3 Pages
    Satisfactory Essays
  • Good Essays

    When it comes down to it, all cancer is genetic. It’s a result of mutations or changes in the DNA sequence of our genes. Genes can be looked at as a set of instructions that tell our cells what to do. Our DNA sequence “spells out” our genes into letters. Mutations are basically errors in the “spelling” of our DNA codes. Most mutations, if they’re minor, can be fixed by our own body’s cells. Problems arise when these mutated or damaged cells begin to reproduce without restraint or when these cells suppress normal cellular growth and repair. These “cancer genes” are classified according to their biological function which either encourages cell growth or suppresses cell growth. Proto-oncogenes normally encourage cell growth and proliferation at the appropriate time. However, when they’re mutated, they function as oncogenes and continually signal cellular growth and division. Tumor suppressor genes normally function to halt cellular growth, but when they’ve been mutated they allow cells to proliferate uncontrollably.…

    • 490 Words
    • 2 Pages
    Good Essays
  • Satisfactory Essays

    HCS 212 wek 4 terms

    • 357 Words
    • 2 Pages

    Cancer is a group of abnormal cells in a certain location or multiple locations of a person’s body.…

    • 357 Words
    • 2 Pages
    Satisfactory Essays
  • Powerful Essays

    Rivaroxaban Case Study

    • 1723 Words
    • 7 Pages

    The cellular analysis revealed that the number of lesions infiltrated with MC was significantly different between the two groups. In contrast, there was no association between the frequency of SMC, CMC and LY (Table V). Specifically all the patients in each group had SMC, the frequency of MC between the S and the U was 9.1% and 63.6% (p=0,02), of LY 9.1% and 27.2% (p=0.65) and of CHC 9,1% and 36,4% (p=0,35)…

    • 1723 Words
    • 7 Pages
    Powerful Essays
  • Good Essays

    Use the car analogy to describe the basic differences between oncogenes and tumor suppressor gene mutations in the development of cancer.…

    • 1184 Words
    • 5 Pages
    Good Essays
  • Good Essays

    Anaplastic rhabdomyosarcoma is not typically found in childhood cancer cases. Embryonal and alveolar are more commonly seen. Embryonal rhabdomyosarcoma ,being the most common, is typically found in the regions by the head, neck, genital, and urinary organs. Alveolar rhabdomyosarcoma is usually found around the legs, arms, genital organs, chest, and anal area. Embryonal rhabdomyosarcoma is found in 55% of patients. Cases of embryonal rhabdomyosarcoma where the patient is under the age of 9 years of age occurs at 70-80%. This type of cancer has a high background mutation rate. It also has a higher single-nucleotide variant rate. The amount of mutations increases with the age the the patient. Alveolar rhabdomyosarcoma occurs at a rate of 20% in patient cases. This type is characterized by its translocations between chromosomes and genes. The alveolar variant is aptly named because of the thin crisscrossing of fibrous bands that show in the spaces between the cellular regions of the tumor site. It is associated with at least one of two translocations of alveolar rhabdomyosarcoma. Also a part of this type is the fusion of DNA-binding domain of neuromuscular developmental transcription…

    • 988 Words
    • 4 Pages
    Good Essays
  • Satisfactory Essays

    The disease has been a focus of researchers worldwide. Most Aids related lymphomas are “high grade” aggressive non hodgkin's lymphoma. Lymphoma is a cancer that starts off in the cells of the lymph system. The lymph system is a part of the immune system that helps the body fight infections and diseases. lymph tissue is found throughout the whole body so lymphoma can start basically…

    • 420 Words
    • 2 Pages
    Satisfactory Essays
  • Satisfactory Essays

    Benign D. Cancers

    • 344 Words
    • 2 Pages

    Summary Statement: Cancer is a condition of uncontrolled growth of abnormal cells that evolve into tumors.…

    • 344 Words
    • 2 Pages
    Satisfactory Essays
  • Good Essays

    According to Half, Rozen, and Brocovich (2009), the APC gene spans a region of 108,353 base pairs and is located on the long arm of chromosome five. They also stated that the mRNA is 10,719 base pairs long and encodes for a protein that has 2,843 amino acids. (Half, et al 2009). Half, Rozen, and Brocovich (2009) reported that mutational analysis of the APC gene indicated that the majority of germline mutations found in patients with FAP are nonsense mutations, leading to the formation of a truncated protein. A nonsense mutation is when a codon is terminated prematurely, resulting in a shortened and in this case a nonfunctional protein. The APC protein contains a mutation cluster region, also known as the MCR, where 60% of the APC mutations occur. This region is located between codons 1284 and 1580. (Half, et. al, 2009). As mentioned before, the APC gene produces a protein called the APC protein. The APC protein binds to the Beta-Catenin to prevent it from interacting with proliferation genes. However, if Beta-Catenin is bound to the mutated or nonfunctional APC protein then it will be able to accumulate and allow excessive proliferation of the colonic epithelial cells, which results in the formation of polyps and eventually tumors in the colon and…

    • 1107 Words
    • 5 Pages
    Good Essays
  • Better Essays

    Multiple Myeloma

    • 2008 Words
    • 9 Pages

    The immune system is made up of several types of cells that work together to fight infections. Lymph cells (called lymphocytes) are the main type of cell in the adaptive immune system. There are 2 types of lymph cells: T cells and B cells. When B cells respond to an infection, they change into plasma cells. The plasma cells are found mainly in the bone marrow—the soft, inner part of some bones. The plasma cells make proteins called antibodies that attack and help kill germs. When plasma cells grow out of control, they can form a tumor, usually in the bone marrow. This type of tumor is called a myeloma, and if there are many tumors they are called multiple myeloma. If there is only one tumor, it is called solitary plasmacytoma. In many cases, this single tumor will go on to become multiple myeloma. Multiple myeloma is characterized by excessive numbers of abnormal plasma cells in the bone marrow and overproduction of intact monoclonal immunoglobulin (IgG, IgA, IgD, or IgE) or Bence-Jones protein (free monoclonal light chains). 1…

    • 2008 Words
    • 9 Pages
    Better Essays