Myo-Inositol Treatment and Gaba-a Receptor Subunit Changes After Kainate- Induced Status Epilepticus

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Cellular and Molecular Neurobiology
ISSN 0272-4340
Volume 33
Number 1
Cell Mol Neurobiol (2013) 33:119-127
DOI 10.1007/s10571-012-9877-4
Myo-Inositol Treatment and GABA-A
Receptor Subunit Changes After Kainate-
Induced Status Epilepticus
Revaz Solomonia, Nana Gogichaishvili,
Maia Nozadze, Eka Lepsveridze, David
Dzneladze & Tamar Kiguradze
123
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ORIGINAL RESEARCH
Myo-Inositol Treatment and GABA-A Receptor Subunit Changes
After Kainate-Induced Status Epilepticus
Revaz Solomonia • Nana Gogichaishvili •
Maia Nozadze • Eka Lepsveridze • David Dzneladze •
Tamar Kiguradze
Received: 16 July 2012 / Accepted: 17 August 2012 / Published online: 18 September 2012
 Springer Science+Business Media, LLC 2012
Abstract Identification of compounds preventing the biochemical changes that underlie the epileptogenesis process is of great importance. We have previously shown that myo-Inositol (MI) daily treatment prevents certain biochemical changes that are triggered by kainic acid
(KA)-induced status epilepticus (SE). The aim of the current work was to study the further influence of MI treatment on the biochemical changes of epileptogenesis and focus on changes in the hippocampus and neocortex of rats for the following GABA-A receptor subunits: a1, a4, c2, and d. After SE, one group of rats was treated with saline, while the second group was treated with MI. Control groups that were not treated by the

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